乳脂摄入与2型糖尿病风险的关联
创作:aluba 审核:aluba 2019年09月07日
  • 纳入3个美国队列的近20万名受试者进行一项前瞻性队列研究,分析乳脂摄入与2型糖尿病风险的关联;
  • 在4219457人-年的随访中,共记录16511例2型糖尿病;
  • 与从碳水化合物中摄入的卡路里相比,乳脂摄入与2型糖尿病风险无显著关联;
  • 用动物脂肪或精制谷物中的碳水化合物替代5%的来自乳脂的卡路里,分别与2型糖尿病风险上升17%及4%相关;
  • 用全谷物中的碳水化合物替代5%的来自乳脂的卡路里,与2型糖尿病风险下降7%相关。
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aluba
American Journal of Clinical Nutrition上发表的一项前瞻性队列研究结果,对20万名受试者随访超过10年后发现,用全谷物代替乳脂与更低的糖尿病风险相关,而用动物脂肪或精致谷物代替乳脂与更高的糖尿病风险相关。
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Dairy fat intake and risk of type 2 diabetes in 3 cohorts of US men and women

3个美国人队列中的乳脂摄入与2型糖尿病

10.1093/ajcn/nqz176

2019-08-14, Article

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BACKGROUND: Previous studies have examined dairy products with various fat contents in relation to type 2 diabetes (T2D) risk, although data regarding dairy fat intake per se are sparse.
OBJECTIVES: We aimed to evaluate the association between dairy fat intake and risk of T2D in 3 prospective cohorts. We also examined associations for isocalorically replacing dairy fat with other macronutrients.
METHODS: We prospectively followed 41,808 men in the Health Professionals Follow-Up Study (HPFS; 1986-2012), 65,929 women in the Nurses' Health Study (NHS; 1984-2012), and 89,565 women in the NHS II (1991-2013). Diet was assessed quadrennially using validated FFQs. Fat intake from dairy products and other relevant sources was expressed as percentage of total energy. Self-reported incident T2D cases were confirmed using validated supplementary questionnaires. Time-dependent Cox proportional hazards regression was used to estimate the HR for dairy fat intake and T2D risk.
RESULTS: During 4,219,457 person-years of follow-up, we documented 16,511 incident T2D cases. Dairy fat was not associated with risk of T2D when compared with calories from carbohydrates (HR for extreme quintiles: 0.98; 95% CI: 0.95, 1.02). Replacing 5% of calories from dairy fat with other sources of animal fat or carbohydrate from refined grains was associated with a 17% (HR: 1.17; 95% CI: 1.13, 1.21) and a 4% (HR: 1.04; 95% CI: 1.00, 1.08) higher risk of T2D, respectively. Conversely, a 5% calorie replacement with carbohydrate from whole grains was associated with a 7% lower risk of T2D (HR: 0.93; 95% CI: 0.88, 0.98).
CONCLUSIONS: Dairy fat intake was not associated with T2D risk in these cohort studies of US men and women when compared with calories from carbohydrate. Replacing dairy fat with carbohydrates from whole grains was associated with lower risk of T2D. Replacement with other animal fats or refined carbohydrates was associated with higher risk.

First Authors:
Andres V Ardisson Korat

Correspondence Authors:
Qi Sun

All Authors:
Andres V Ardisson Korat,Yanping Li,Frank Sacks,Bernard Rosner,Walter C Willett,Frank B Hu,Qi Sun

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