益生菌对血清脂联素及瘦素水平无显著影响
创作:szx 审核:szx 2018年10月23日
  • 纳入12项在成年人中进行的临床试验进行荟萃分析,研究益生菌、益生元及合生制剂对血清中的脂联素及瘦素的影响;
  • 其中10项研究关注益生菌,2项研究关注益生元,1项研究关注合生制剂,受试者包括肥胖、2型糖尿病、前列腺癌、非酒精性脂肪性肝病(NAFLD)患者及健康人;
  • 使用的益生菌大多为乳杆菌属、双歧杆菌属的菌株,益生元主要是低聚果糖;
  • 相比于对照组,益生菌对血清中的脂联素及瘦素水平均无显著影响,各亚组分析的结果也相似。
主编推荐语
szx
Clinical Nutrition上发表的一项荟萃分析结果,在12项临床试验中,使用益生菌干预对成年人(包括各类疾病患者及健康人)血清中的脂联素及瘦素水平无显著影响。
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Do probiotics, prebiotics and synbiotics affect adiponectin and leptin in adults? A systematic review and meta-analysis of clinical trials

益生菌、益生元及合生制剂影响成年人的脂联素和瘦素吗?对临床试验的系统性综述及荟萃分析

10.1016/j.clnu.2018.09.033

2018-10-12, Review

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Background & aims: Human studies have reported controversial findings regarding the health promoting effects of probiotic, prebiotic and synbiotic on adiponectin and leptin levels. This systematic review and meta-analysis was conducted to understand the effect of probiotics, prebiotics or synbiotics on adiponectin and leptin levels in adults.
Methods: Electronic searches were performed in PubMed, Scopus, Web of Science, Cochrane Library and Google scholar up to February 11, 2018 without any restriction. Controlled clinical trials, in any age of adults, which reported the effect of probiotic, prebiotic and synbiotic on serum level of adiponectin and leptin were included. As leptin and adiponectin were reported in different units across the studies, Hedges's adjusted g was used to calculate effect size. A random-effects model was used to pool calculated effect sizes.
Results: Of 12 eligible studies, 10 publications focused on probiotics, and only 3 studies reported the effect of prebiotics (n = 2) or synbiotics (n = 1) on leptin and adiponectin. There were no significant changes in adiponectin (Hedges' g = −0.04; 95% CI: −0.27, 0.19) and leptin (Hedges' g = −0.30; 95% CI: −0.86, 0.26) in probiotic group compared with controls. Subgroup analyses ranged in heterogeneity from 0% to 93%, but no subgroup showed an effect of probiotics on adiponectin or leptin.
Conclusion: There were limited studies regarding the effect of prebiotic and synbiotic on adiponectin and leptin. Although previous studies reported several health promoting effects of probiotics, we could not find any pooled effect on adiponectin and leptin.

First Authors:
Mohammad Hossein Rouhani

Correspondence Authors:
Hamed Mohammadi

All Authors:
Mohammad Hossein Rouhani,Amir Hadi,Ehsan Ghaedi,Mina Salehi,Atena Mahdavi,Hamed Mohammadi

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