浙大团队:新橙皮苷改变肠道菌群,预防小鼠大肠癌
创作:szx 审核:szx 2019年11月25日
  • 在APC min/+转基因结直肠癌小鼠模型中,喂食新橙皮苷可诱导肿瘤细胞的凋亡及抑制血管新生,以抑制高脂饮食诱导的结直肠癌肿瘤发生;
  • 在细胞水平上发现,新橙皮苷对肿瘤的抑制作用并非来自于其对肿瘤细胞的直接作用;
  • 新橙皮苷可改变小鼠的肠道菌群组成,降低拟杆菌门的丰度,并增加厚壁菌门及变形菌门的丰度;
  • 粪菌移植实验证实,移植喂食了新橙皮苷小鼠的粪菌,可显著抑制肿瘤发生。
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szx
新橙皮苷是一种柑橘类水果提取物,可能对多种疾病有着治疗及预防的效果。来自浙江大学的团队在Pharmacological Research上发表的一项最新研究,发现在结直肠癌小鼠模型中,新橙皮苷可通过改变肠道菌群组成,而抑制结直肠肿瘤发生。
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Neohesperidin Prevents Colorectal Tumorigenesis by Altering the Gut Microbiota

新橙皮苷通过改变肠道菌群以预防结直肠肿瘤的发生

10.1016/j.phrs.2019.104460

2019-09-24, Article

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Neohesperidin (NHP), derived from citrus fruits, has attracted considerable interest due to its preventative and therapeutic effects on numerous diseases. However, little progress has been made in determining the exact function of NHP on tumorigenesis. In the current study, we found that NHP inhibited colorectal tumorigenesis in the APC min/+ transgenic mouse model, as well as induced apoptosis and blocked angiogenesis in vivo. Our in-cell study suggested that this tumorigenic preventative effect of NHP is not due to the direct impact on tumor cells. Intriguingly, by utilizing 16 s rRNA gene-based microbiota sequencing, the relative abundance of Bacteroidetes was decreased, while Firmicutes and Proteobacteria were increased in the presence of NHP. Additionally, the fecal microbiota transplantation experiment further revealed that feeding with fecal of NHP-treated mice induced considerable inhibition of tumorigenesis, which indicates that the alteration of gut microbiota is responsible for NHP-mediated prevention of colorectal tumorigenesis. Thus, our study not only suggests the efficacy of NHP as a potent natural product for preventing colorectal cancer but also proposes a compelling model to connect the gut microbiota to the preventative effect of NHP on tumorigenesis.

First Authors:
Yanling Gong,Rong Dong,Xiaomeng Gao

Correspondence Authors:
Ji Cao,Qiaojun He

All Authors:
Yanling Gong,Rong Dong,Xiaomeng Gao,Jin Li,Li Jiang,Jiale Zheng,Sunliang Cui,Meidan Ying,Bo Yang,Ji Cao,Qiaojun He

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