国内团队:肠道菌群介导了红细胞γ-亚麻酸与2型糖尿病间的关联
创作:orchid 审核:szx 2020年09月01日
  • 纳入2731名无2型糖尿病的受试者,在6.2年的随访期间,确诊了276例2型糖尿病患者;
  • 较高的红细胞γ-亚麻酸(GLA)水平,而非亚油酸或花生四烯酸水平,与较高的2型糖尿病的发病率相关;
  • 基线GLA与随访期间的肠道菌群丰富度及多样性呈显著负相关,并与菌群β多样性显著相关,菌群的α-多样性是GLA与2型糖尿病之间关联的潜在介导因素;
  • 丁酸弧菌属、布劳特氏菌属、颤螺旋菌属等菌属在GLA水平最低的受试者及无2型糖尿病的受试者中富集。
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szx
西湖大学的郑钜圣团队与中山大学的陈裕明团队在Diabetes Care上发表的一项前瞻性队列研究,对近3000名受试者进行6年左右的随访后发现,红细胞中较高的γ-亚麻酸水平与较高的2型糖尿病风险相关,而对比分析不同亚组的肠道菌群多样性及组成,发现上述关联可能由菌群差异所介导。
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Diabetes Care [IF:16.019]

Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota, and Incident Type 2 Diabetes: A Prospective Cohort Study

红细胞n-6多不饱和脂肪酸、肠道菌群和2型糖尿病的发病率:一项前瞻性队列研究

10.2337/dc20-0631

2020-07-28, Article

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OBJECTIVE: To examine the association of erythrocyte n-6 polyunsaturated fatty acid (PUFA) biomarkers with incident type 2 diabetes and explore the potential role of gut microbiota in the association.
RESEARCH DESIGN AND METHODS: We evaluated 2,731 participants without type 2 diabetes recruited between 2008 and 2013 in the Guangzhou Nutrition and Health Study (Guangzhou, China). Case subjects with type 2 diabetes were identified with clinical and biochemical information collected at follow-up visits. Using stool samples collected during the follow-up in the subset (n = 1,591), 16S rRNA profiling was conducted. Using multivariable-adjusted Poisson or linear regression, we examined associations of erythrocyte n-6 PUFA biomarkers with incident type 2 diabetes and diversity and composition of gut microbiota.
RESULTS: Over 6.2 years of follow-up, 276 case subjects with type 2 diabetes were identified (risk 0.10). Higher levels of erythrocyte γ-linolenic acid (GLA), but not linoleic or arachidonic acid, were associated with higher type 2 diabetes incidence. Comparing the top to the bottom quartile groups of GLA levels, relative risk was 1.72 (95% CI 1.21, 2.44) adjusted for potential confounders. Baseline GLA was inversely associated with gut microbial richness and diversity (α-diversity, both P < 0.05) during follow-up and significantly associated with microbiota β-diversity (P = 0.002). α-Diversity acted as a potential mediator in the association between GLA and type 2 diabetes (P < 0.05). Seven genera (Butyrivibrio, Blautia, Oscillospira, Odoribacter, S24-7 other, Rikenellaceae other, and Clostridiales other) were enriched in quartile 1 of GLA and in participants without type 2 diabetes.
CONCLUSIONS: Relative concentrations of erythrocyte GLA were positively associated with incident type 2 diabetes in a Chinese population and also with gut microbial profiles. These results highlight that gut microbiota may play an important role linking n-6 PUFA metabolism and type 2 diabetes etiology.

First Authors:
Zelei Miao

Correspondence Authors:
Yu-ming Chen,Jusheng Zheng

All Authors:
Zelei Miao,Jie-sheng Lin,Yingying Mao,Geng-dong Chen,Fang-fang Zeng,Hong-li Dong,Zengliang Jiang,Jiali Wang,Congmei Xiao,Menglei Shuai,Wanglong Gou,Yuanqing Fu,Fumiaki Imamura,Yu-ming Chen,Jusheng Zheng

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