草药可以减肥吗?
创作:orchid 审核:兵兵 2020年04月18日
  • 纳入54项随机对照试验,同一草药有4项及以上的研究且减重在2.5kg以上被认为有减肥功效;
  • 单独使用菜豆,以及菜豆、茶(Camellia sinensis)与草麻黄的联合制剂,能够导致统计学上的体重减轻,但并不具有临床意义;
  • 单独使用茶或藤黄果没有减重效果;
  • 在试验数量不足4项的研究结果中,非洲芒果、方茎青紫葛、绒毛戴星草与山竹联用,可能有减重效果,但是需要进一步验证;
  • 干预期≤12周时,大部分草药对人体安全。
主编推荐语
兵兵
文章系统综述了几种常见草药的减肥有效性。以具有4项及以上研究支持,且减重2.5kg为指标,筛选出菜豆、及其与茶和草麻黄的联合制剂,具有统计学上的减肥效果,但不具有临床意义。其他草药则实验证据不足或者减肥效果不显著。因此,文章认为目前仍没有足够的证据说明草药具有减肥效果。
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Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

草药减肥的有效性:随机对照试验的系统评价和荟萃分析

10.1111/dom.13973

2020-01-27, Review

Abstract & Authors:展开

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Aim: To update the available evidence on the efficacy and safety of complementary medicines to assist in weight loss by conducting a systematic review and meta‐analysis of herbal medicines for weight loss.
Methods: Four electronic databases (Medline, Embase, CINAHL and Web of Science) were searched from inception until August 2018. A total of 54 randomized placebo‐controlled trials of healthy overweight or obese adults were identified. Meta‐analyses were conducted for herbal medicines with ≥4 studies available. Weight differences of ≥2.5 kg were considered clinically significant.
Results: As a single agent, only Phaseolus vulgaris resulted in a statistically significant weight loss compared to placebo, although this was not considered clinically significant. No effect was seen for Camellia sinensis or Garcinia cambogia. Statistically, but not clinically, significant differences were observed for combination preparations containing C. sinensis, P. vulgaris or Ephedra sinica. Of the herbal medicines trialled in ≤3 randomized controlled trials, statistically and clinically significant weight loss compared to placebo was reported for Irvingia gabonensis, Cissus quadrangularis, and Sphaeranthus indicus combined with Garcinia mangostana, among others, but these findings should be interpreted cautiously because of the small number of studies, generally poor methodological quality, and poor reporting of the herbal medicine interventions. Most herbal medicines appeared safe for consumption over the short duration of the studies (commonly ≤12 weeks). Some warrant further investigation to determine effect size, dosage and long‐term safety.
Conclusion: There is currently insufficient evidence to recommend any of the herbal medicines for weight loss included in the present review.

First Authors:
Alison Maunder

Correspondence Authors:
Erica Bessell

All Authors:
Alison Maunder,Erica Bessell,Romy Lauche,Jon Adams,Amanda Sainsbury,Nicholas R Fuller

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