植物乳杆菌P8或可缓解压力焦虑、改善记忆认知
创作:药农 审核:szx 2019年12月28日
  • 103名马来西亚成年人随机分为2组,52名补充益生菌——植物乳杆菌P8,51名补充安慰剂,持续12周,研究益生菌对中度压力状态下成年人心理、记忆和认知的影响;
  • 4周后,相比于安慰剂组,益生菌组的压力、焦虑得分及PSS-10问卷总得分显著降低,血浆皮质醇水平稍有下降(不显著),IFN-γ、TNF-α等促炎因子的水平显著降低;
  • 益生菌组的社会情绪认知、口头学习和记忆能力得到了显著提高;
  • 益生菌对受试者各项指标的影响存在性别差异。
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来自Clinical Nutrition上报道的一项随机双盲安慰剂对照试验的结果,在103名马来西亚成年人中,发现补充植物乳杆菌P8可显著缓解压力、焦虑,并降低血浆中的炎症因子,提升记忆及认知能力。另外,益生菌对受试者的影响存在性别差异。
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Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo 

益生菌植物乳杆菌P8缓解压力和焦虑,增强受压成人的记忆和认知:一项随机、双盲、安慰剂对照研究

10.1016/j.clnu.2018.09.010

2018-09-19, Article

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Background & aims: To investigate the effects of probiotic in alleviation of stress in stressed adults, along our focus to identify and justify strain specificity on selected health benefits with a precisely targeted population.
Methods: This 12-weeks randomized, double-blind and placebo-controlled study investigated the effects of a probiotic (Lactobacillus plantarum P8; 10 log CFU daily) on psychological, memory and cognition parameters in one hundred and three (P8 n = 52, placebo n = 51) stressed adults with mean age of 31.7 ± 11.1 years old. All subjects fulfilled the criteria of moderate stress upon diagnosis using the PSS-10 questionnaire.
Results: At the end of study, subjects on P8 showed reduced scores of stress (mean difference 2.94; 95% CI 0.08 to 5.73; P = 0.048), anxiety (mean difference 2.82; 95% CI 0.35 to 5.30; P = 0.031) and total score (mean difference 8.04; 95% CI 0.73 to 15.30; P = 0.041) as compared to placebo after 4-weeks, as assessed by the DASS-42 questionnaire. Although plasma cortisol levels were only marginally different between placebo and P8 (mean difference 3.28 ug/dl; 95% CI -7.09 to 0.52; P = 0.090), pro-inflammatory cytokines such as IFN-γ (mean difference 8.07 pg/ml; 95% CI -11.2 to −4.93; P < 0.001) and TNF-α (mean difference 1.52 pg/ml; 95% CI -2.14 to −0.89; P < 0.001) showed higher reduction as compared to placebo over 12-weeks. These were accompanied by enhanced memory and cognitive traits such as social emotional cognition and verbal learning and memory upon administration of P8 as compared to the placebo, with different effects in women as compared to men.
Conclusions: The present data illustrated that L. plantarum P8 is a feasible and natural intervention for the alleviation of selected stress, anxiety, memory and cognitive symptoms in stressed adults.
Trial registration: Approved by the JEPeM-USM Review Panel on Clinical Studies (Approval number USM/JEPeM/16050195) and was registered at ClinicalTrials.gov (identifier number NCT03268447).

First Authors:
Lee-Ching Lew

Correspondence Authors:
Heping Zhang,Min-Tze Liong

All Authors:
Lee-Ching Lew,Yan-Yan Hor,Nur Asmaa' A Yusoff,Sy-Bing Choi,Muhamad S B Yusoff,Nurhanis S Roslan,Anisa Ahmad,Jamilah A M Mohammad,Mohammad Farris I L Abdullah,Norzila Zakaria,Normala Wahid,Zhihong Sun,Lai-Yu Kwok,Heping Zhang,Min-Tze Liong

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临床试验 | 植物乳杆菌P-8舒缓压力及焦虑

2019-10-31

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