浙江省中医院:培菲康可减少抗生素诱导的肠道菌群失调
  • 196名静脉注射β-内酰胺类抗生素的患者随机分为3组:对照组、培菲康常规剂量组及双剂量组,干预14天;
  • 在抗生素治疗的7天内,各组的肠道菌群失调发生率分别为21.88%、14.93%和6.15%,
  • 在第8-14天,各组的肠道菌群失调发生率分别为25%,14.93%和4.62%;
  • 双剂量组的肠道菌群失调发生率均显著低于对照组;
  • 抗生素治疗显著减少肠道细菌OTU,培菲康可恢复,且双剂量组的菌群物种丰富度(尤其是副拟杆菌属等)高于常规剂量组及对照组。
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浙江中医药大学附属第一医院的吕宾团队在Gut Pathogens上发表的一项随机对照试验结果,在196名使用β-内酰胺类抗生素的患者中,发现口服培菲康(含有长双歧杆菌、嗜酸乳杆菌、及粪肠球菌)可以剂量依赖性方式降低抗生素诱导的肠道菌群失调的发生率,并恢复肠道菌群的物种丰富度。
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Gut Pathogens [IF:4.181]

The prophylactic effects of BIFICO on the antibiotic-induced gut dysbiosis and gut microbiota

培菲康对抗生素诱导的肠道失调和肠道菌群的预防作用

10.1186/s13099-020-00379-0

2020-09-09, Article

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Background: The aim of this study is to evaluate the prophylactic effects of probiotic mixture BIFICO on antibiotic-induced gut dysbiosis (AIGD) and the influence on the change of the gut microbiota.
Methods: We conducted a prospective, randomized, controlled study and divided 196 patients who required intravenous beta-lactam antibiotics into three groups: a control group (no probiotics), a regular group (840 mg of BIFICO), and a double-dosage group (1680 mg of BIFICO). The symptoms of antibiotic-related diarrhea, bloating and abdominal pain and the incidence of AIGD were evaluated 7 days and 8–14 days after antibiotic use, with 10 patients in each group. 16S rDNA sequencing was performed to detect changes of the gut microbiota.
Results: Within 7 days of the initiation of antibiotic treatment, the incidences of AIGD in the control group, regular group (840 mg of BIFICO), and double-dosage group (1680 mg of BIFICO) were 21.88%, 14.93%, and 6.15% respectively. On days of 8–14th, the incidences of AIGD in the control group, regular group, and double-dosage group were 25%, 14.93%, and 4.62%, respectively. The incidence of AIGD in the double-dosage group within 7 days and 14 days were both significantly lower than that in relevant control group (P < 0.05). On day 14, the incidence of AIGD in the double-dosage group was lower than that in the regular group (P < 0.05). The number of operational taxonomic units (OTUs) in the control group after antibiotic treatment was significantly reduced compared to that prior to treatment, while those of the regular and double-dosage groups were stable. The species abundance, especially Parabacteroides, Phascolarctobacterium and Roseburia, of the double-dosage group was greater than that of the regular group and the control group.
Conclusions: BIFICO may reduce the occurrence of AIGD in a dose-dependent manner and can stabilize the gut microbiota balance.

First Authors:
Jiannong Wu

Correspondence Authors:
Bin Lv

All Authors:
Jiannong Wu,Tieer Gan,Ying Zhang,Guolian Xia,Shu Deng,Xin Lv,Bingxin Zhang,Bin Lv

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