大连医科大学等:中国妈妈的母乳对婴儿肠道菌群有何影响
  • 分析56对中国母婴在哺乳期间的母乳与婴儿粪便样本;
  • 岩藻糖转移酶2(FUT2)基因变异状态影响母乳中的总人乳寡糖(HMO)和岩藻糖基化HMO的丰度,尤其在泌乳早期;
  • 母乳中的乳蛋白浓度在泌乳期内呈下降趋势,但N-聚糖的岩藻糖基化水平在泌乳后期增加;
  • 岩藻糖基化HMO和N-聚糖水平的改变,在泌乳早期和晚期分别与婴儿肠道中的双歧杆菌和乳杆菌的生长高度相关;
  • 取决于FUT2变异的母亲分泌型对婴儿肠道菌群的影响,与特定菌群功能通路有关。
主编推荐语
mildbreeze
mSystems近期发表了大连医科大学李明和中国科学院大连化学物理研究所闫竞宇团队共同主导的研究。该研究首次分析了6个月哺乳期内,由FUS2基因多态性决定的分泌型状态对中国女性母乳中人乳寡糖和N-聚糖的岩藻糖基化水平的影响,及其对婴儿肠道菌群的作用。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
mSystems [IF:6.633]

Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different 

中国母乳中的岩藻糖基化人乳低聚糖和N-聚糖调节不同泌乳阶段母乳喂养婴儿的肠道微生物组

10.1128/mSystems.00206-18

2018-12-26, Article

Abstract & Authors:展开

Abstract:收起
The milk glycobiome has a significant impact on the gut microbiota of infants, which plays a pivotal role in health and development. Fucosylated human milk oligosaccharides (HMOs) and N-glycans on milk proteins are beneficial for the development of healthy gut microbiota, and the fucosylation levels of these glycans can be affected by the maternal fucosyltransferase 2 gene (FUT2). Here, we present results of longitudinal research on paired milk and stool samples from 56 Chinese mothers (CMs) and their breast-fed children. Changes of HMOs and fucosylated N-glycans in milk of CMs at different lactation stages were detected, which allowed characterization of the major differences in milk glycans and consequential effects on the gut microbiome of infants according to maternal FUT2 status. Significant differences in the abundance of total and fucosylated HMOs between secretor and nonsecretor CMs were noted, especially during early lactation. Despite a tendency toward decreasing milk protein concentrations, the fucosylation levels of milk N-glycans increased during late lactation. The changes in the levels of fucosylated HMOs and milk N-glycans were highly correlated with the growth of Bifidobacterium spp. and Lactobacillus spp. in the gut of infants during early and later lactation, respectively. Enriched expression of genes encoding glycoside hydrolases, glycosyl transferases, ATP-binding cassette (ABC) transporters, and permeases in infants fed by secretor CMs contributed to the promotion of these bacteria in infants. Our data highlight the important role of fucosylated milk glycans in shaping the gut microbiome of infants and provide a solid foundation for development of “personalized” nutrition for Chinese infants.

First Authors:
Yaqiang Bai

Correspondence Authors:
Jingyu Yan,Ming Lia

All Authors:
Yaqiang Bai,Jia Tao,Jiaorui Zhou,Qingjie Fan,Man Liu,Yuqi Hu,Yao Xu,Lilong Zhang,Jieli Yuan,Wenzhe Li,Xiaolei Ze,Patrice Malard,Zhimou Guo,Jingyu Yan,Ming Lia

评论