微生物如何影响乳腺癌发病和治疗?(综述)
创作:Lexi 审核:Lexi 2020年09月14日
  • 乳腺/肠道菌群或与乳腺癌(BC)有关,一类胃肠道微生物可影响雌激素代谢和激素循环/分泌平衡;
  • 免疫相关基因表达、免疫浸润、特定肠道菌群丰度与较好的BC临床结果相关;
  • 肠道菌群的影响可促进人BC高甲基化和表观遗传重编程,并推动肿瘤进程;
  • 在饮食相关BC中,微生物介导的机制或是致癌和肿瘤侵袭调节因子;
  • 临床前研究表明益生菌可作为预防和控制BC进展的调节剂,并增强宿主免疫;
  • 膳食生物活性化合物或可作为化疗预防BC的辅助治疗。
主编推荐语
Lexi
现有的大部分数据表明,乳腺癌与肠道微环境和乳腺组织中的细菌生态失调有关。最新发表在Cancers的综述就乳腺和肠道微生物在乳腺癌发病机制中的作用作了详细总结。这些发现可以为建立新的乳腺癌预防和治疗策略提供新的见解。
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Cancers [IF:6.126]

Breast and Gut Microbiota Action Mechanisms in Breast Cancer Pathogenesis and Treatment

乳腺和肠道微生物在乳腺癌发病和治疗中的作用机制

10.3390/cancers12092465

2020-08-31, Review

Abstract & Authors:展开

Abstract:收起
In breast cancer (BC) the employment of sequencing technologies for metagenomic analyses has allowed not only the description of the overall metagenomic landscape but also the specific microbial changes and their functional implications. Most of the available data suggest that BC is related to bacterial dysbiosis in both the gut microenvironment and breast tissue. It is hypothesized that changes in the composition and functions of several breast and gut bacterial taxa may contribute to BC development and progression through several pathways. One of the most prominent roles of gut microbiota is the regulation of steroid-hormone metabolism, such as estrogens, a component playing an important role as risk factor in BC development, especially in postmenopausal women. On the other hand, breast and gut resident microbiota are the link in the reciprocal interactions between cancer cells and their local environment, since microbiota are capable of modulating mucosal and systemic immune responses. Several in vivo and in vitro studies show remarkable evidence that diet, probiotics and prebiotics could exert important anticarcinogenic effects in BC. Moreover, gut microbiota have an important role in the metabolism of chemotherapeutic drugs and in the activity of immunogenic chemotherapies since they are a potential dominant mediator in the response to cancer therapy. Then, the microbiome impact in BC is multi-factorial, and the gut and breast tissue bacteria population could be important in regulating the local immune system, in tumor formation and progression and in therapy response and/or resistance.

First Authors:
Aurora Laborda-Illanes

Correspondence Authors:
Emilio Alba,María Isabel Queipo-Ortuño

All Authors:
Aurora Laborda-Illanes,Lidia Sanchez-Alcoholado,María Emilia Dominguez-Recio,Begoña Jimenez-Rodriguez,Rocío Lavado,Iñaki Comino-Méndez,Emilio Alba,María Isabel Queipo-Ortuño

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