创作:周旸 审核:周旸 02月03日
  • 糖尿病与肥胖人群对新冠病毒的易感性并未升高,但这类人群的住院率更高、病情更严重,2型糖尿病与不良预后相关;
  • 年轻人群的BMI和新冠肺炎严重程度正相关 ,但该关系并非都是线性的,受成人心脏代谢问题的影响较大;
  • 针对新冠病毒的免疫反应、病毒清除、RNA疫苗有效性上,无明确证据表明糖尿病、肥胖人群与普通人群有异;
  • 新冠肺炎住院患者中,高血糖症状与激素药物使用相关;
  • 虽不排除可能性,新冠病毒直接感染胰岛β细胞的概率极小。
新冠肺炎全球蔓延至今,住院患者的肥胖、糖尿病和心血管风险因素成为科研和医学转化的关注点。Cell Metabolism近期发表综述,回顾了2020年初至今对于肥胖/糖尿病与新冠肺炎的相关性研究,指出代谢风险因素与新冠肺炎发生、发展与预后的研究仍然有许多空缺,强调了需要关注新冠肺炎对于代谢疾病的长期影响。该综述对于系统性了解代谢疾病与新冠肺炎的关联、合理制定对症治疗手段具有参考价值。
Cell Metabolism [IF:21.567]

Diabetes, obesity, metabolism and SARS-CoV-2 infection: The end of the beginning



01-21, Review

Abstract & Authors:展开

The increased prevalence of obesity, diabetes and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology. Here, I update concepts informing how metabolic disorders and their comorbidities modify the susceptibility to, natural history and potential treatment of SARS-CoV-2 infection, with a focus on human biology. New data informing genetic predisposition, epidemiology, immune responses, disease severity and therapy of COVID-19 in people with obesity and diabetes are highlighted. The emerging relationships of metabolic disorders to viral-induced immune responses and viral persistence, and the putative importance of adipose and islet ACE2 expression, glycemic control, cholesterol metabolism, and glucose- and lipid-lowering drugs is reviewed, with attention to controversies and unresolved questions. Rapid progress in these areas informs our growing understanding of SARS-CoV-2 infection in people with diabetes and obesity, while refining the therapeutic strategies and research priorities in this vulnerable population.

First Authors:
Daniel J Drucker

Correspondence Authors:
Daniel J Drucker

All Authors:
Daniel J Drucker