帕金森病患者的肠道菌群组成及功能变化
创作:szx 审核:szx 2020年06月26日
  • 分析对比223名PD患者及137名对照的肠道菌群,并综合4个已报道的数据集进行荟萃分析,总结PD患者的肠道菌群组成及功能变化;
  • 校正BMI、便秘、性别、年龄、用药情况等干扰因素后,Akkermansia菌属(可降解肠道黏液层)、Catabacter菌属及Akkermansiaceae菌科在PD患者中富集;
  • Roseburia菌属、粪杆菌属(两者均为短链脂肪酸产生菌)及毛螺菌科ND3007在PD患者中减少;
  • 通过功能分析鉴定出PD患者的肠道菌群中19个通路上调,3个通路下调。
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szx
帕金森病(PD)可能起源于α-突触核蛋白在肠道中的累积,与肠道菌群失调相关,但在不同国家的研究中观察到的PD患者的肠道菌群变化并不一致。《Movement Disorders》上发表的一项荟萃分析结果,对223名PD患者及137名对照的肠道菌群进行测序,并将该结果与4个不同国家(美国、芬兰、俄罗斯、德国)的数据集进行综合分析,鉴定出了在不同国家的PD患者中均存在的菌群变化:可降解肠道黏液层的Akkermansia菌属增加,而Roseburia菌属、粪杆菌属等短链脂肪酸产生菌减少。
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Movement Disorders [IF:8.679]

Meta-Analysis of Gut Dysbiosis in Parkinson's Disease

对帕金森病患者的肠道菌群失调的荟萃分析

10.1002/mds.28119

2020-06-18, Article

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BACKGROUND: PD may begin with the intestinal accumulation of α-synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD.
OBJECTIVES: To identify gut dysbiosis in PD across countries.
METHODS: We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta-analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method.
RESULTS: After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol-O-methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol-O-methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta-analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short-chain fatty acid metabolisms in our dataset.
CONCLUSIONS: We report that intestinal mucin layer-degrading Akkermansia is increased and that short-chain fatty acid-producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society.

First Authors:
Hiroshi Nishiwaki

Correspondence Authors:
Masaaki Hirayama,Kinji Ohno

All Authors:
Hiroshi Nishiwaki,Mikako Ito,Tomohiro Ishida,Tomonari Hamaguchi,Tetsuya Maeda,Kenichi Kashihara,Yoshio Tsuboi,Jun Ueyama,Teppei Shimamura,Hiroshi Mori,Ken Kurokawa,Masahisa Katsuno,Masaaki Hirayama,Kinji Ohno

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