低晚期糖基化终末产物饮食可改善部分代谢指标
创作:szx 审核:szx 2020年12月27日
  • 纳入13项RCT研究进行荟萃分析,总结AGE对代谢综合征风险因素(包括腰围、血压、糖代谢、胰岛素抵抗/分泌、脂代谢等相关指标)的影响;
  • 干预时间从2周到48周不等,5项研究涉及2型糖尿病患者,5项研究涉及肥胖/超重患者,1项研究涉及多囊卵巢综合征患者;
  • 相比于摄入高AGE饮食的个体,摄入低AGE饮食的个体的胰岛素抵抗、空腹胰岛素、总胆固醇、LDL胆固醇均显著降低;
  • 对于其它代谢综合征风险因素,低AGE饮食组与高AGE饮食组无显著差异。
主编推荐语
szx
加工食品中富含晚期糖基化终末产物(AGE),后者是蛋白质、脂质或核酸等物质的游离氨基与糖反应后形成的一类终末产物,具有促炎症及促氧化的作用。Advances in Nutrition上发表的一项荟萃分析结果,总结了13项RCT研究的数据后发现,低AGE饮食可显著改善受试者的胰岛素抵抗,并降低空腹胰岛素、总胆固醇及LDL胆固醇水平。
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The Impact of Low Advanced Glycation End Products Diet on Metabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

低晚期糖基化终末产物饮食对代谢风险因素的影响:对随机对照试验的系统性综述与荟萃分析

10.1093/advances/nmaa150/6012826

2020-11-30, Article

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Several randomized clinical trials have investigated the effect of dietary advanced glycation end products (AGEs) on metabolic syndrome risk factors in adults. However, the results of these studies were conflicting. Therefore, our aim was to assess the effect of dietary AGEs on metabolic syndrome risk factors. We searched the PubMed-MEDLINE, Scopus, Cochrane Databases, Google Scholar, Web of Science, and Embase databases for papers published up to October 2019 that investigated the effect of dietary AGEs on metabolic syndrome risk factors. From the eligible trials, 13 articles were selected for inclusion in this systematic review and meta-analysis. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I2 statistics and Cochrane Q test. Pooled results from the random-effects model showed a significant reduction for insulin resistance [weighted mean difference (WMD): −1.204; 95% CI: −2.057, −0.358; P = 0.006], fasting insulin (WMD: −5.472 μU/mL; 95% CI: −9.718, −1.234 μU/mL; P = 0.011), total cholesterol (WMD: −5.486 mg/dL; 95% CI: −10.222, −0.747 mg/dL; P = 0.023), and LDL (WMD: −6.263 mg/dL; 95% CI: −11.659, −0.866 mg/dL; P = 0.023) in the low-AGEs groups compared with the high-AGEs groups. There were no changes in the other components of the metabolic syndrome. The results of this review suggest that a diet with a low AGEs content has beneficial effects on insulin resistance, fasting insulin, total cholesterol, and LDL. Moreover, following a diet low in AGEs may be a helpful strategy to decrease the burden of metabolic syndrome risk factors in adults and particularly in patients with diabetes.

First Authors:
Mohammad Hasan Sohouli,Somaye Fatahi

Correspondence Authors:
Farzad Shidfar

All Authors:
Mohammad Hasan Sohouli,Somaye Fatahi,Elham Sharifi-Zahabi,Heitor O Santos,Nishant Tripathi,Abolfazl Lari,Behnaz Pourrajab,Hamed Kord-Varkaneh,Mihnea-Alexandru Găman,Farzad Shidfar

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