青岛大学:EPA与DHA对代谢综合征相关指标的不同影响
创作:aluba 审核:aluba 07月18日
  • 纳入33项随机对照试验(30项平行设计、3项交叉设计)进行荟萃分析,总结EPA及DHA对代谢综合征相关指标的影响;
  • EPA与DHA均可有效降低血清甘油三酯水平;
  • EPA可显著降低血清总胆固醇、甘油三酯及LDL-胆固醇的水平,而DHA可显著增加血清总胆固醇、LDL-胆固醇及HDL-胆固醇的水平;
  • 另外,相比于EPA,DHA可显著增加血清胰岛素水平,尤其是在平均年龄小于60岁及补充DHA少于3个月的受试者中。
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青岛大学的李铎团队在Clinical Nutrition上发表的一项荟萃分析结果,总结了33项随机对照试验的数据,对比分析了二十碳五烯酸(EPA)及二十二碳六烯酸(DHA)对代谢综合征相关指标的不同影响。
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Clinical Nutrition [IF:7.324]

Effects of dietary eicosapentaenoic acid and docosahexaenoic acid supplementation on metabolic syndrome: A systematic review and meta-analysis of data from 33 randomized controlled trials

饮食二十碳五烯酸及二十二碳六烯酸补充对代谢综合征的影响:对33项随机对照试验的系统性综述与荟萃分析

10.1016/j.clnu.2021.05.025

06-05, Article

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Background & aims: Previous randomized controlled trials (RCTs) have compared the effects of pure preparations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in reducing metabolic syndrome (MetS) risk factors, but the results were inconsistent. The present study aimed to clarify whether EPA and DHA have differential effects on MetS features in humans.
Methods: A systematic literature search was conducted in CNKI, PubMed, Embase and Scopus updated to February 2021. The mean changes in the characteristics of MetS were calculated as weighted mean differences by using a random-effects model. Thirty-three RCTs were included.
Results: The results showed that both EPA and DHA were effective at lowering serum triglycerides (TG) levels. EPA supplementation decreased the serum levels of total cholesterol (TC) (WMD = −0.24 mmol/L; 95% CI, −0.43, −0.05 mmol/L), TG (WMD = −0.77 mmol/L; 95% CI, −1.54, −0.00 mmol/L) and low density lipoprotein-cholesterol (LDL-C) (WMD = −0.13 mmol/L; 95% CI, −0.25, −0.01 mmol/L), while DHA increased the serum levels of TC (WMD = 0.14 mmol/L; 95% CI, 0.03, 0.25 mmol/L), LDL-C (WMD = 0.26 mmol/L; 95% CI, 0.15, 0.38 mmol/L) and high density lipoprotein-cholesterol (HDL-C) (WMD = 0.07 mmol/L; 95% CI, 0.04, 0.09 mmol/L). Moreover, DHA increased the serum levels of insulin compared with EPA, especially in subgroups whose mean age was <60 years (0.43 mU/L; 95% CI: 0.04, 0.81 mU/L) and duration of DHA supplementation < 3 months (0.39 mU/L; 95% CI: 0.01, 0.77 mU/L).
Conclusions: The present meta-analysis provides evidence that EPA and DHA have different effects on risk factors of MetS.

First Authors:
Hui-Jun Zhang,Xiang Gao

Correspondence Authors:
Duo Li

All Authors:
Hui-Jun Zhang,Xiang Gao,Xiao-Fei Guo,Kelei Li,Shan Li,Andrew J Sinclair,Duo Li

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