国内团队:益生元包封的益生菌微胶囊,或能改善代谢疾病
创作:fang fang 审核:兵兵 2020年09月23日
  • 利用微流技术,包封乳酸菌和枯草芽孢杆菌到益生元海藻酸盐的独立隔室制成双核微胶囊;
  • 微胶囊具有良好的抗酸性能,可保持益生菌的活性和功能;
  • 两种益生菌互不干扰,又协同作用,促进增殖并提高效能;
  • 在高脂饮食的实验代谢综合征小鼠中,单独的益生菌微胶囊可减轻肠道炎症反应、保护肠道屏障,有效缓解肝内脂肪沉积,双核微胶囊效果更为显著;
  • 双核微胶囊增强益生元和益生菌的协同作用,在治疗代谢综合征及相关疾病方面具有潜力。
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兵兵
深圳大学第一附属医院阎德文、Hui Tan和复旦大学商珞然与团队共同研究成果。文章采用微流技术,利用益生元海藻酸盐将乳酸菌和枯草芽孢杆菌进行独立双核微胶囊。该微胶囊可以保持益生菌的活性,协同作用且又不互相干扰,可以最大程度发挥有益效力,在干预代谢性相关疾病方面具有很大潜力。
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Dual-core Prebiotics Microcapsule Encapsulating Probiotics for Metabolic Syndrome

用于代谢综合征的双核的益生元微胶囊包封的益生菌

10.1021/acsami.0c13518

2020-09-01, Article

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Designing strategies to utilize the synergistic effect of probiotics and prebiotics is a promising way in treating metabolic-related diseases. Here, inspired by the mutually promotable but mutually incompatible characteristics of Yin and Yang, dual-core microcapsules that encapsulate Lactobacillus and Bacillus subtilis into separate compartments were presented through electrostatically-driven microfluidics. The microcapsules showed acid resistance and preserved probiotics activity. They also fostered the proliferation of probiotics while creating an anaerobic environment and promoted lactic acid fermentation without affecting each other. It has been demonstrated that the microcapsules could reduce inflammation, improve fat metabolism and restore intestinal barrier function, thus contributing to the treatment of metabolic syndrome in vivo. These features make the dual-core microcapsules an ideal candidate for treating metabolic syndrome and related diseases.

First Authors:
Cheng Zhao

Correspondence Authors:
Dewen Yan,Hui Tan,Luoran Shang

All Authors:
Cheng Zhao,Yujuan Zhu,Bin Kong,Yutong Huang,Dewen Yan,Hui Tan,Luoran Shang

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