Cell:工业化加速了人肠道菌群中的基因转移
  • 对来自不同程度的工业化和非工业化地区的15个人群的>4000份肠道菌群进行培养、分离和测序,其中包括来自单个个体的富集菌株;
  • 发现上千个细菌种属间,基因水平转移(HGT)的比率和目标不同;
  • 近几代宿主的菌群中积累了HGT,并且HGT在个体中发生的频率很高,且具有异质性;
  • 对不同的人群进行比较研究,工业化的生活方式与较高的HGT比率有关,近期发生的HGT的功能与宿主的工业化水平有关。
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爱的抉择
工业化影响了人类肠道生态系统,改变了微生物的组成和多样性。细菌基因组是否也能适应宿主种群的工业化,目前尚不清楚。Cell最新发表的文章,通过对工业化和非工业化地区的15个人群的肠道细菌进行分析,发现基因的水平转移(HGT)在近几代宿主的肠道菌群中积累,发生频率很高,而且工业化的生活方式与较高的HGT比率有关。即肠道细菌在适应宿主生活方式的基础上不断获得新的功能,较高速率的HGT可能与人类历史中工业化发展有关。
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Cell [IF:38.637]

Elevated rates of horizontal gene transfer in the industrialized human microbiome

工业化环境下,人类微生物群中基因水平转移的比率升高

10.1016/j.cell.2021.02.052

03-31, Article

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Abstract:收起
Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization.

First Authors:
Mathieu Groussin,Mathilde Poyet

Correspondence Authors:
Mathieu Groussin,Mathilde Poyet,Eric J Alm

All Authors:
Mathieu Groussin,Mathilde Poyet,Ainara Sistiaga,Sean M Kearney,Katya Moniz,Mary Noel,Jeff Hooker,Sean M Gibbons,Laure Segurel,Alain Froment,Rihlat Said Mohamed,Alain Fezeu,Vanessa A Juimo,Sophie Lafosse,Francis E Tabe,Catherine Girard,Deborah Iqaluk,Le Thanh Tu Nguyen,B Jesse Shapiro,Jenni Lehtima¨ ki,Lasse Ruokolainen,Pinja P Kettunen,Tommi Vatanen,Shani Sigwazi,Audax Mabulla,Manuel Domı´nguez-Rodrigo,Yvonne A Nartey,Adwoa Agyei-Nkansah,Amoako Duah,Yaw A Awuku,Kenneth A Valles,Shadrack O Asibey,Mary Y Afihene,Lewis R Roberts,Amelie Plymoth,Charles A Onyekwere,Roger E Summons,Ramnik J Xavier,Eric J Alm

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