创作:Epi汪 审核:Epi汪 2020年04月10日
  • 纳入华中科技大学附属同济医院7名新冠病毒阳性孕妇,平均32岁,平均孕39+1周;
  • 临床症状主要为发热(占86%)、咳嗽、气促、腹泻;
  • 7名孕妇均在入院3日内剖宫产,母婴状况良好,出生体重均在3000g以上,出生Apgar评分均在8-9分;
  • 其中3名新生儿接受SARS-CoV-2检测,两例阴性,有一例阳性,但预后良好,没有观察到任何并发症;
  • 通过尽可能周全、积极的健康管理可以保护感染的孕妇不发生严重妊娠不良结局,其与文献报道相一致。

Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study



2020-03-24, Article

Abstract & Authors:展开

Background: In December, 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19.
Methods: In this retrospective, single-centre study, we included all pregnant women with COVID-19 who were admitted to Tongji Hospital in Wuhan, China. Clinical features, treatments, and maternal and fetal outcomes were assessed.
Findings: Seven patients, admitted to Tongji Hospital from Jan 1, to Feb 8, 2020, were included in our study. The mean age of the patients was 32 years (range 29–34 years) and the mean gestational age was 39 weeks plus 1 day (range 37 weeks to 41 weeks plus 2 days). Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. The fnal date of follow up was Feb 12, 2020. The outcomes of the pregnant women and neonates were good. Three neonates were tested for SARS-CoV-2 and one neonate was infected with SARS-CoV-2 36 h after birth.
Interpretation: The maternal, fetal, and neonatal outcomes of patients who were infected in late pregnancy appeared very good, and these outcomes were achieved with intensive, active management that might be the best practice in the absence of more robust data. The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature.

First Authors:
Nan Yu,Wei Li

Correspondence Authors:
Jianli Wu

All Authors:
Nan Yu,Wei Li,Qingling Kang,Zhi Xiong,Shaoshuai Wang,Xingguang Lin,Yanyan Liu,Juan Xiao,Haiyi Liu,Dongrui Deng,Suhua Chen,Wanjiang Zeng,Ling Feng,Jianli Wu