Nature子刊:肠道菌群的PUFA代谢物,帮助抵抗肥胖
创作:Kang 审核:mildbreeze 2019年10月01日
  • 高脂饮食(HFD)改变小鼠肠道菌群组成,抑制多不饱和脂肪酸(PUFA)的菌群代谢物(如亚油酸LA的衍生物HYA)生成;
  • 补充HYA可抑制食欲、改善糖脂代谢,减轻HFD诱导的小鼠肥胖,定植生成HYA的乳杆菌也有相似效果;
  • HYA通过调节游离脂肪酸相关的G蛋白偶联受体GPR40和GPR120,促进肠道激素GLP-1分泌,改善糖稳态;
  • 还作用于前列腺素受体EP3,促进肠道蠕动,从而减少脂质吸收;
  • 菌群将LA转化为HYA可减少LA引起的花生四烯酸介导的脂肪炎症。
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mildbreeze
膳食多不饱和脂肪酸(PUFA)对健康和代谢有重要影响。Nature Communications近期发表的研究表明,肠道菌群可将饮食中的n-6 PUFA代谢为HYA(10-羟基-顺-12-十八碳烯酸,亚油酸的衍生物)等代谢产物,HYA有助于减少过量膳食亚油酸引起的脂肪炎症,还能抑制食欲、改善糖脂代谢,从而帮助小鼠抵抗高脂饮食诱导的肥胖。这些发现为靶向肠道菌群及其代谢物来改善代谢疾病,带来新思路。
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Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

肠道微生物群通过代谢膳食多不饱和脂肪酸赋予宿主对肥胖的抵抗力

10.1038/s41467-019-11978-0

2019-09-05, Article

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Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.

First Authors:
Junki Miyamoto

Correspondence Authors:
Ikuo Kimura

All Authors:
Junki Miyamoto,Miki Igarashi,Keita Watanabe,Shin-ichiro Karaki,Hiromi Mukouyama,Shigenobu Kishino,Xuan Li,Atsuhiko Ichimura,Junichiro Irie,Yukihiko Sugimoto,Tetsuya Mizutani,Tatsuya Sugawara,Takashi Miki,Jun Ogawa,Daniel J Drucker,Makoto Arita,Hiroshi Itoh,Ikuo Kimura

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