药物与保健品的潜在不良互作,应引起重视
  • 分析英格兰155名65周岁以上、服用过≥1种处方药的老人的调查问卷,发现33.6%的人并存使用草药产品(HMP)和膳食补充剂,女性比男性更普遍;
  • 大部分(78%)为膳食补充剂与处方药共用,常见为鱼肝油、葡萄糖胺、复合维生素和维生素D;
  • 与处方药共用的HMP多为月见草油、缬草和Nytol草药®;
  • 32.6%的共用者面临潜在的药物不良互作的风险;
  • 应关注老人的草药和补充剂的使用情况,可辨别和管理潜在得药物不良互作风险。
主编推荐语
mildbreeze
老年人大多患有慢性病,需要长期服药。同时,老年人也是保健品的主要使用群体。British Journal of General Practice近期发表一项研究,发现英国老年人中,约1/3存在处方药与草药产品/膳食补充剂等保健品并存使用的现象,有药物不良互作风险,因此服用保健品前最好先咨询清楚,避免与相冲的药物共用。
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Prevalence of drug-herb and drug-supplement interactions in older adults: a cross-sectional survey

老年人的药物-草药及药物-补充剂相互作用的普遍情况:一项横断面调查

10.3399/bjgp18X699101

2018-09-27, Article

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BACKGROUND: Polypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults.
AIM: To establish prevalence of concurrent prescription drugs, HMPs, and dietary supplements among UK community-dwelling older adults and identify potential interactions.
DESIGN AND SETTING: Cross-sectional survey of older adults registered at two general practices in South East England.
METHOD: A questionnaire asking about prescription medications, HMPs, and sociodemographic information was posted to 400 older adults aged ≥65 years, identified as taking ≥1 prescription drug.
RESULTS: In total 155 questionnaires were returned (response rate = 38.8%) and the prevalence of concurrent HMPs and dietary supplements with prescriptions was 33.6%. Females were more likely than males to be concurrent users (43.4% versus 22.5%; = 0.009). The number of HMPs and dietary supplements ranged from 1 to 8, (mean = 3, median = 1; standard deviation = 1.65). The majority of concurrent users (78.0%) used dietary supplements with prescription drugs. The most commonly used dietary supplements were cod liver oil, glucosamine, multivitamins, and vitamin D. Others (20.0%) used only HMPs with prescription drugs. Common HMPs were evening primrose oil, valerian, and Nytol Herbal (a combination of hops, gentian, and passion flower). Sixteen participants (32.6%) were at risk of potential adverse drug interactions.
CONCLUSION: GPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions.

First Authors:
Taofikat B Agbabiaka

Correspondence Authors:
Taofikat B Agbabiaka

All Authors:
Taofikat B Agbabiaka,Neil H Spencer,Sabina Khanom,Claire Goodman

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