中国农大:母猪妊娠期和哺乳期内肠道菌群和代谢变化
创作:大力 审核:周旸 2019年01月24日
  • 与哺乳期相比,母猪在妊娠期的肠道菌群组成、短链脂肪酸(SCFA)代谢产物、微生物与SCFA的相关性与非妊娠期更为相似;
  • 无论是荣昌猪还是长白猪,科里杆菌科和埃希菌属在妊娠期逐渐增多;
  • 哺乳期内,两种的母猪肠道中产SCFA细菌以及SCFA的含量均增加,妊娠期和非妊娠期之间无显著差别;
  • 妊娠会对肠道菌群结构产生影响,而哺乳期的肠道菌群结构保持相对稳定;
  • 荣昌猪肠道中瘤胃球菌科的丰度更高,与荣昌猪更强的纤维消化能力一致。
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周旸
菌群在宿主生理变化过程中也会发生改变。本文利用猪作为模型,揭示了妊娠期、哺乳期和非妊娠期母体微生物的结构和代谢变化,可为改善母猪甚至人类的妊娠和哺乳提供参考。
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FASEB Journal [IF:5.391]

Microbial and metabolic alterations in gut microbiota of sows during pregnancy and lactation

母猪妊娠期和哺乳期肠道菌群的微生物和代谢变化

10.1096/fj.201801221RR

2019-01-17, Article

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The gut microbiota plays a critical role in various physiologic processes; however, maternal microbial and metabolic changes during pregnancy and lactation remain elusive. Using pigs as an animal model, we conducted comparative analyses of gut microbiota and short-chain fatty acid (SCFA) profiles across different stages of gestation, lactation, and the empty (nonpregnancy) phase in 2 distinct breeds of sow, Rongchang (RS) and Landrace (LS). Coriobacteriaceae were found to gradually increase over gestational time irrespective of breed, which was further validated in an independent cohort of sows, indicating that Coriobacteriaceae are likely associated with the progression of pregnancy. Escherichia increased as well. Relative to empty and gestation, lactation was associated with an increase in SCFA producers and a concomitant augmentation in SCFA production in both breeds. A comparison between the 2 breeds revealed that Ruminococcaceae were more abundant in RSs than in LSs, consistent with the strong ability of Rongchang pigs to digest highly fibrous feedstuffs. Taken together, we revealed characteristic structural and metabolic changes in maternal gut microbiota throughout pregnancy, lactation, and the empty phase, which could potentially help improve the pregnancy and lactation outcomes for both animals and humans.-Liu, H., Hou, C., Li, N., Zhang, X., Zhang, G., Yang, F., Zeng, X., Liu, Z., Qiao, S. Microbial and metabolic alterations in gut microbiota of sows during pregnancy and lactation.

First Authors:
Hongbin Liu

Correspondence Authors:
Xiangfang Zeng

All Authors:
Hongbin Liu,Chengli Hou,Ning Li,Xiaoya Zhang,Guolong Zhang,Feiyun Yang,Xiangfang Zeng,Zuohua Liu,Shiyan Qiao

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