母乳,协助婴儿免疫系统发育的重要因素(综述)
创作:Epi汪 审核:Epi汪 05月01日
  • 胎儿的免疫系统是在一个相对无菌的环境中发育的,因此可能缺乏抗原刺激;
  • 产后,婴儿摄入母乳,其可以帮助传递母亲的免疫细胞,并协助婴儿免疫系统发育;
  • 有关于母乳中的白细胞等免疫细胞的作用,近期被广泛研究;
  • 婴儿的消化道可以协助母乳中白细胞存活,并将其转运至组织内;
  • 母乳中的白细胞可能来源于肠道、上呼吸道粘膜等,并在新生儿的免疫系统中发挥重要作用;
  • 通过母乳传递白细胞可能是影响新生儿免疫系统发育的重要因素。
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Epi汪
本综述总结了目前有关母乳中免疫细胞的功能,以及婴儿免疫系统发育的证据。为进一步相关领域的研究提供方向指导。
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Maternal Leukocytes and Infant Immune Programming during Breastfeeding

母亲白细胞与婴儿哺乳期免疫系统发展

10.1016/j.it.2020.01.005

03-01, Article

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The fetal immune system develops in a rather sterile environment relative to the outside world and, therefore, lacks antigenic education. Soon after birth, the newborn is exposed to the hostile environment of pathogens. Recently, animaland limited human-based studies have indicated that help from the mother, upon transfer of leukocytes and their products via breast milk feeding, greatly assists the newborn’s immune system. Here, I discuss the newest advances on how milk leukocytes impact early life immunity, with an emphasis on the development of the infant T cell repertoire and early immune responses in the periphery and gut-associated lymphoid tissue. A deeper understanding of these novel mechanistic insights may inform potential translational approaches to improving immunity in infants.

First Authors:
Amale Laouar

Correspondence Authors:
Amale Laouar

All Authors:
Amale Laouar

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