Nature Reviews:代谢疾病中的肠道菌群与代谢炎症(一图读懂)
  • 肥胖、2型糖尿病和脂肪肝等代谢疾病存在肠道菌群失调,潜在的促炎和致病菌增多、有益菌减少;
  • 饮食成分、菌群及其代谢物与肠粘膜免疫互作,菌群失调、高脂饮食、高血糖和腹泻等因素可诱导肠粘膜的炎性环境,破坏肠屏障;
  • 肠屏障损伤使菌群产生的内毒素、细菌成分和代谢物移位进入循环系统,促进慢性代谢炎症,相关肝脏疾病削弱了肝脏清除这些有害物的能力,加剧炎症;
  • 益生元、益生菌和后生元,或能改善菌群失调、肠屏障和代谢炎症。
#一张图读懂系列文献#
主编推荐语
mildbreeze
低度炎症是代谢疾病的一大特征,越来越多证据显示,这些疾病中存在肠道菌群及其代谢物的变化和肠道屏障功能障碍。菌群及其代谢物穿过肠道屏障发生移位,对肠道以外的代谢器官产生影响,促进代谢炎症。Nature Reviews Immunology发表的重磅综述,探讨了肠道菌群和肠屏障功能紊乱在代谢炎症中的作用。我们将其中的插图改制为一图读懂,希望能助你涨知识。
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The intestinal microbiota fuelling metabolic inflammation

促进代谢炎症的肠道菌群

10.1038/s41577-019-0198-4

2019-08-06, Article

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Low- grade inflammation is the hallmark of metabolic disorders such as obesity , type 2 diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites, which translocate from the gut across a disrupted intestinal barrier to affect various metabolic organs, such as the liver and adipose tissue, thereby contributing to metabolic inflammation. Here, we discuss some of the recently identified mechanisms that showcase the role of the intestinal microbiota and barrier dysfunction in metabolic inflammation. We propose a concept by which the gut microbiota fuels metabolic inflammation and dysregulation.

First Authors:
Herbert Tilg

Correspondence Authors:
Herbert Tilg,Eran Elinav

All Authors:
Herbert Tilg,Niv Zmora,Timon E Adolph,Eran Elinav

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