马曦团队:营养、菌群与肠道表观遗传调控(综述)
  • 营养干预、益生菌、菌群移植和健康生活方式,通过肠道菌群调节肠道和远端器官的健康;
  • 肠道菌群能直接或间接地调控肠道表观遗传修饰(核酸甲基化、miRNA、组蛋白乙酰/基化和血清素化等),从而介导菌群与肠粘膜屏障之间的“对话”;
  • 例如:乳杆菌和双歧杆菌可合成叶酸,增加肠道DNA甲基化和mRNA的N6-甲基腺嘌呤修饰,确保肠道正常发育;
  • 梭菌、厌氧棒状菌和真杆菌可产生丁酸,诱导组蛋白乙酰化修饰,促进肠道的发育和免疫平衡;
主编推荐语
mildbreeze
肠道菌群可以通过多种机制与宿主发生相互作用,从而影响宿主健康。中国农业大学马曦团队近期在Critical Reviews in Food Science and Nutrition,详细介绍了饮食等干预方法对肠道菌群的塑造作用,重点探讨了菌群对肠道的表观遗传调控机制,并对未来的发展进行了展望,值得专业人士参考。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

膳食营养素通过表观遗传修饰塑造肠道菌群和肠黏膜

10.1080/10408398.2020.1828813

2020-10-12, Review

Abstract & Authors:展开

Abstract:收起
The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and function, then further damages the functions and homeostasis of distal organs, leading to systemic diseases. Nutrients, transplantation of bacteria flora and modes of life can shape gut microbiota and intestinal mucosa barrier and mitigate stress. Current researches demonstrate that dynamic epigenetic modifications of intestinal tissue strongly mediate the crosstalk between gut microbes and gut mucosa barrier. and species can synthesize folate to increase DNA methylation and mRNA N6-methyladenosine (m6A) of gut, which ensures intestinal normal development. , and can induce histone acylation modifications by butyrate to enhance the development and immune balance of gut. Herein, we summarizes the present scientific understanding of how dietary nutrients shape gut microbiota and further regulate intestinal mucosa functions via epigenetic modifications, which will shed light on manipulation of gut microbiota by dietary nutrients, for prevention or clinical treatment of intestinal diseases.

First Authors:
Jianmin Wu

Correspondence Authors:
Xi Ma

All Authors:
Jianmin Wu,Ying Zhao,Xian Wang,Lingchang Kong,Lee J Johnston,Lin Lu,Xi Ma

评论