地中海饮食依从性与结直肠癌风险无关
创作:szx 审核:szx 2019年09月16日
  • 纳入120852名荷兰受试者,随访20.3年期间,1993名男性及1574名女性被诊断出结直肠癌;
  • 使用替代性地中海饮食评分(含有酒精:aMED;不含有酒精:aMEDr)评估受试者对地中海饮食的依从性;
  • 在男性及女性中,aMED及aMEDr与结直肠癌风险均无显著关联,且与不同部位的结直肠癌(结肠、近端结肠、远端结肠、直肠)也无关联;
  • 在女性中,aMEDr与结直肠癌风险的关联受到吸烟的影响。
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szx
地中海饮食被认为有益健康。European Journal of Epidemiology上发表的一项前瞻性队列研究结果,对超过12万名荷兰人进行20年随访后发现,地中海饮食依从性与结直肠癌风险并无显著关联。
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Mediterranean diet adherence and risk of colorectal cancer: the prospective Netherlands Cohort Study

地中海饮食依从性与结直肠癌风险:前瞻性荷兰队列研究

10.1007/s10654-019-00549-8

2019-09-07, Article

Abstract & Authors:展开

Abstract:收起
Mediterranean diet (MD) adherence has been associated with a large variety of health benefits. However, prospective studies investigating the relation between MD adherence and colorectal cancer risk had inconsistent results. In this analysis of the Netherlands Cohort Study (NLCS), we evaluated sex- and subsite-specific associations of MD adherence with colorectal cancer risk. In 1986, 120,852 subjects filled out the NLCS baseline questionnaire, which incorporated a 150-item food frequency questionnaire. MD adherence was estimated through alternate Mediterranean diet scores including and excluding alcohol (aMED and aMEDr, respectively). Using 20.3 year follow-up data, 1993 male and 1574 female colorectal cancer cases could be included in multivariable case-cohort analyses. aMEDr was not significantly associated with colorectal cancer risk, regardless of sex. Hazard ratios (95% confidence intervals) per two-point increment were 1.04 (0.95-1.13) for men and 0.97 (0.88-1.07) for women. Additionally, there was no evidence of an inverse association with any of the colorectal cancer subsites (colon, proximal colon, distal colon, and rectum). In women, the association between aMEDr and colorectal cancer risk was significantly modified by smoking status (P = 0.015). Comparable results were obtained for the original aMED including alcohol. In conclusion, higher MD adherence was not associated with a reduced risk of colorectal cancer or anatomical subsites in the context of a Dutch population.

First Authors:
Maya Schulpen

Correspondence Authors:
Piet A van den Brandt

All Authors:
Maya Schulpen,Piet A van den Brandt

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