生酮饮食禁忌症的最新科学证据 (综述)
创作:orchid 审核:mildbreeze 2020年09月27日
  • 生酮饮食(KD)可用于治疗顽固性癫痫、肥胖、2型糖尿病、神经疾病等,但也有很多禁忌症;
  • 纳入52项研究调查KD对特定脆弱人群的安全性;
  • KD可用于非酒精性脂肪肝炎、轻度慢性肾病,但不推荐用于怀孕和哺乳期、肾癌和黑色素瘤、围手术期和感染期;
  • 终末期肝病、终末期肾病、1型糖尿病、心脑血管损伤、呼吸衰竭、非肥胖的高尿酸血症和血脂紊乱、老年虚弱、精神病和酒精/药物滥用者,若使用KD需由相关专家进行评估、监测和量身定制。
主编推荐语
mildbreeze
近年研究显示,生酮饮食在治疗一些慢性疾病方面有不错的效果,但作为一种比较极端的饮食模式,生酮饮食的安全性仍存在诸多疑虑,这限制了其在疾病干预中的应用。Obesity Reviews近期发表的综述文章,对目前的研究证据和知识缺口进行了总结,推荐专业人士参考。
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Obesity Reviews [IF:7.31]

Scientific evidence underlying contraindications to the ketogenic diet: An update

生酮饮食禁忌症的科学证据:最新动态

10.1111/obr.13053

2020-07-10, Article

Abstract & Authors:展开

Abstract:收起
First identified as a feasible treatment for intractable epilepsy, the ketogenic diet (KD) has recently gained popularity thanks to growing evidence on applications such as weight loss, most importantly, but also NAFLD, cancer, neurologic conditions and chronic pain. As with any treatment, whether pharmacologic or not, the KD might not be an appropriate intervention for every individual, and a number of contraindications have been proposed, now deeply rooted into clinical practice, excluding de facto many patients that could benefit from its use. However, many of these concerns were expressed due to the absence of clinical studies conducted on fragile populations, and an assessment of lately emerged evidence relative to KD safety is currently lacking and much needed. We herein provide a critical revision of the literature behind each safety alert, in order to guide through the treatment options in the case of subjects with an indication to the KD and a borderline safe situation. Based on available evidence, the possible use of this diet as a therapeutic intervention should be assessed on a patient‐to‐patient basis by adequately skilled medical doctors, keeping in mind current recommendations, but reading them through the knowledge of the current state of the art.

First Authors:
Mikiko Watanabe

Correspondence Authors:
Mikiko Watanabe

All Authors:
Mikiko Watanabe,Dario Tuccinardi,Ilaria Ernesti,Sabrina Basciani,Stefania Mariani,Alfredo Genco,Silvia Manfrini,Carla Lubrano,Lucio Gnessi

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