Nature:幼年期的特定神经细胞,影响进食时间对生物钟的调控
  • 光信号通过光敏性视网膜神经节细胞(ipRGC)传递到视交叉上核(SCN)和膝状体间小叶(IGL);
  • 产后早期(而非晚期)缺失ipRGC细胞的小鼠,成年后对限时进食的生物钟同步现象变弱;
  • 生命早期的ipRGC神经支配可影响表达NPY的IGL神经元(IGLNPY),促进IGLNPY–SCN功能性神经回路组装;
  • 抑制IGLNPY和产后早期敲除ipRGC,都能够降低时间调控的进食行为发生;
  • 因此,对限时进食的生物钟同步,依赖于生命早期ipRGC对IGL–SCN回路的调节作用。
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mildbreeze
光照和进食是影响生物钟的主要时间因素,《Nature》近期发表的一项研究表明,限时进食对生物钟的影响作用,依赖于特定的神经回路,而该神经回路的建立受幼年期光敏性视网膜神经节细胞的调控。
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Nature [IF:42.778]

Retinal innervation tunes circuits that drive nonphotic entrainment to food

视网膜干预可调控驱动非光性进食夹带的环路

10.1038/s41586-020-2204-1

04-22, Article

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Daily changes in light and food availability are major time cues that influence circadian timing1. However, little is known about the circuits that integrate these time cues to drive a coherent circadian output1,2,3. Here we investigate whether retinal inputs modulate entrainment to nonphotic cues such as time-restricted feeding. Photic information is relayed to the suprachiasmatic nucleus (SCN)—the central circadian pacemaker—and the intergeniculate leaflet (IGL) through intrinsically photosensitive retinal ganglion cells (ipRGCs)4. We show that adult mice that lack ipRGCs from the early postnatal stages have impaired entrainment to time-restricted feeding, whereas ablation of ipRGCs at later stages had no effect. Innervation of ipRGCs at early postnatal stages influences IGL neurons that express neuropeptide Y (NPY) (hereafter, IGLNPY neurons), guiding the assembly of a functional IGLNPY–SCN circuit. Moreover, silencing IGLNPY neurons in adult mice mimicked the deficits that were induced by ablation of ipRGCs in the early postnatal stages, and acute inhibition of IGLNPY terminals in the SCN decreased food-anticipatory activity. Thus, innervation of ipRGCs in the early postnatal period tunes the IGLNPY–SCN circuit to allow entrainment to time-restricted feeding.

First Authors:
Diego Carlos Fernandez

Correspondence Authors:
Diego Carlos Fernandez,Samer Hattar

All Authors:
Diego Carlos Fernandez,Ruchi Komal,Jennifer Langel,Jun Ma,Phan Q Duy,Mario A Penzo,Haiqing Zhao,Samer Hattar

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