华大基因等:素食对肠道菌群和免疫有何影响?
  • 15名健康杂食者进行为期3个月的蛋奶素食饮食干预,免疫系统的多样性和宏基因组的整体构成无显著变化;
  • 但肠道菌群中普遍存在已知的有益菌属/种(如产丁酸盐菌和益生菌种,及与平衡自身免疫相关的变异基因/科)和与IgA(保护胃肠黏膜系统)表达相关的一些细菌种属;
  • 长期素食者T细胞多样性和 IgE表达水平较低,肠道菌群中炎症相关基因大量减少,可能与饮食有关;
  • 饮食成分和持续时间或可影响肠道菌群和免疫系统中促/抗炎因子的平衡。
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mildbreeze
华大基因团队参与的一项研究近期在Frontiers in Immunology发表,首次用宏基因组测序分析了素食对肠道菌群和免疫的影响,表明短期素食(3个月)对免疫系统和菌群宏基因组没有显著改变,但长期素食可能使菌群的“炎症性”下降。
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Impact of a three-months Vegetarian Diet on the Gut Microbiota and Immune Repertoire

为期3个月的素食对肠道菌群和免疫组库的影响

10.3389/fimmu.2018.00908

2018-04-27, Article

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The dietary pattern can influence the immune system directly, but may also modulate it indirectly by regulating the gut microbiota. Here, we investigated the effect of a 3-months lacto-ovo-vegetarian diet on the diversity of gut microbiota and the immune system in healthy omnivorous volunteers, using high-throughput sequencing technologies. The short-term vegetarian diet did not have any major effect on the diversity of the immune system and the overall composition of the metagenome. The prevalence of bacterial genera/species with known beneficial effects on the intestine, including butyrate-producers and probiotic species and the balance of autoimmune-related variable genes/families were, however, altered in the short-term vegetarians. A number of bacterial species that are associated with the expression level of IgA, a key immunoglobulin class that protects the gastrointestinal mucosal system, were also identified. Furthermore, a lower diversity of T-cell repertoire and expression level of IgE, as well as a reduced abundance of inflammation-related genes in the gut microbiota were potentially associated with a control group with long-term vegetarians. Thus, the composition and duration of the diet may have an impact on the balance of pro-/anti-inflammatory factors in the gut microbiota and immune system.

First Authors:
Chenchen Zhang,Andrea Björkman,Kaiye Cai

Correspondence Authors:
Kaiye Cai,Qiang Pan-Hammarström

All Authors:
Chenchen Zhang,Andrea Björkman,Kaiye Cai,Guilin Liu,Chunlin Wang,Yin Li,Huihua Xia,Lijun Sun,Karsten Kristiansen,Jun Wang,Jian Han,Lennart Hammarström,Qiang Pan-Hammarström

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