袁静+刘翟+杨瑞馥:高产酒精的肠道菌可引起脂肪肝
  • 从非酒精性脂肪性肝病(NAFLD)患者肠道菌群中,分离出高酒精产力(HiAlc)的肺炎克雷伯菌(Kpn);
  • 在一个NAFLD队列中约60%的患者携带HiAlc Kpn,且与疾病程度相关;
  • 菌株定植和粪菌移植等实验表明,HiAlc Kpn通过产生内源性酒精诱导线粒体损伤来引起小鼠NAFLD,并破坏肠屏障,增加Th17等免疫细胞,加剧肝脏炎症;
  • HiAlc Kpn+高脂饮食进一步促进小鼠NAFLD进展;
  • 口服葡萄糖后测量血液酒精浓度,或可检测HiAlc细菌和由其引发的脂肪肝。
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mildbreeze
非酒精性脂肪性肝病(NAFLD)的病因比较多样化,近年研究表明这种疾病与肠道菌群的改变有密切关联。首都儿科研究所袁静、中科院武汉病毒研究所刘翟、北京微生物流行病研究所杨瑞馥与团队在Cell Metabolism发表的最新研究发现,有相当比例的脂肪肝患者肠道中存在能产生大量酒精的肺炎克雷伯菌,这些细菌产生的内源性酒精是非酒精性脂肪肝的一个重要诱因。这些发现不仅解释了为什么NAFLD与酒精性脂肪肝之间存在很多相同的病理特征,还为临床上诊断和治疗由这类细菌引起的脂肪肝提供了可行方法。
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Cell Metabolism [IF:21.567]

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

由高酒精产力的肺炎克雷伯菌导致的非酒精性脂肪肝疾病

10.1016/j.cmet.2019.08.018

2019-09-19, Article

Abstract & Authors:展开

Abstract:收起
The underlying etiology of nonalcoholic fatty liver disease (NAFLD) is believed to be quite varied. Changes in the gut microbiota have been investigated and are believed to contribute to at least some cases of the disease, though a causal relationship remains unclear. Here, we show that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) is associated with up to 60% of individuals with NAFLD in a Chinese cohort. Transfer of clinical isolates of HiAlc Kpn by oral gavage into mice induced NAFLD. Likewise, fecal microbiota transplant (FMT) into mice using a HiAlc-Kpn-strain-containing microbiota isolated from an individual with NASH induced NAFLD. However, selective elimination of the HiAlc Kpn strain before FMT prevented NAFLD in the recipient mice. These results suggest that at least in some cases of NAFLD an alteration in the gut microbiome drives the condition due to excess endogenous alcohol production.

First Authors:
Jing Yuan,Chen Chen,Jinghua Cui,Jing Lu,Chao Yan

Correspondence Authors:
Jing Yuan,Ruifu Yang,Di Liu

All Authors:
Jing Yuan,Chen Chen,Jinghua Cui,Jing Lu,Chao Yan,Xiao Wei,Xiangna Zhao,NanNan Li,Shaoli Li,Guanhua Xue,Weiwei Cheng,Boxing Li,Huan-Huan Liu,Weishi Lin,Changyu Tian,Jiangtao Zhao,Juqiang Han,Daizhi An,Qiong Zhang,Hong Wei,Minghua Zheng,Xuejun Ma,Wei Li,Xiao Chen,Zheng Zhang,Hui Zeng,Sun Ying,JianXin Wu,Ruifu Yang,Di Liu

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热心肠研究院新闻网站

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点评:热心肠日报配发的本文通讯作者专访。

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