丽水二院:中国阿尔兹海默症患者的肠道菌群变化
创作:Echo Quasimodo 审核:szx 03月02日
  • 纳入100名丽水的AD患者和71名年龄性别匹配的健康对照,对粪便菌群进行对比分析;
  • AD患者的粪便菌群多样性及丰富度显著降低,分类群组成显著改变;
  • AD患者的粪便菌群中,粪杆菌属等产丁酸菌属显著减少,这些细菌与MMSE等量表评分呈正相关,而双歧杆菌等产乳酸菌属显著增加,这些细菌与量表评分呈负相关;
  • AD患者粪便菌群中的脂肪酸生物合成及代谢、叶酸生物合成等通路的丰度发生显著改变;
  • AD患者的粪便菌群失调可能促进宿主免疫紊乱。
主编推荐语
szx
丽水市第二人民医院的吴绍长团队在Frontiers in Cell and Developmental Biology上发表的一项病例-对照研究结果,鉴定了100名阿尔兹海默症(AD)患者及71名健康对照的粪便菌群多样性、组成及功能差异。该研究结果提示,肠道菌群或可作为AD早期诊断的非侵入性生物标志物。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease

中国阿尔兹海默症患者的粪便菌群结构和功能失调

10.3389/fcell.2020.634069

02-04, Article

Abstract & Authors:展开

Abstract:收起
Increasing evidence suggests that gut dysbiosis plays vital roles in a variety of gut–brain disorders, such as Alzheimer's disease (AD). However, alterations of the gut microbiota as well as their correlations with cognitive scores and host immunity have remained unclear in well-controlled trials on Chinese AD patients. In this study, samples from 100 AD patients, and 71 age- and gender-matched, cognitively normal controls were obtained to explore the structural and functional alterations of the fecal microbiota targeting the V3–V4 region of the 16S rRNA gene by MiSeq sequencing, and to analyze their associations with clinical characteristics. Our data demonstrated a remarkably reduction in the bacterial diversity and alterations in the taxonomic composition of the fecal microbiota of the AD patients. Interestingly, the abundant butyrate-producing genera such as Faecalibacterium decreased significantly, where this was positively correlated with such clinical indicators as the MMSE, WAIS, and Barthel scores in the AD patients. On the contrary, abundant lactate-producing genera, such as Bifidobacterium, increased prominently, and were inversely correlated with these indicators. This shift in the gut dysbiosis of the microbiota, from being butyrate producers to lactate producers, contributed to immune disturbances in the host that could be used as non-invasive biomarkers to distinguish the controls from the AD patients. Moreover, several predicted functional modules, including the biosynthesis and the metabolism of fatty acids, that were altered in the microbiota of the AD patients could be utilized by the bacteria to produce immunomodulatory metabolites. Our study established the structural and functional dysbiosis of fecal microbiota in AD patients, and the results suggest the potential for use of gut bacteria for the early, non-invasive diagnosis of AD, personalized treatment, and the development of tailor-made probiotics designed for Chinese AD patients.

First Authors:
Zongxin Ling,Manlian Zhu,Xiumei Yan,Yiwen Cheng,Li Shao,Xia Liu

Correspondence Authors:
Shaochang Wu

All Authors:
Zongxin Ling,Manlian Zhu,Xiumei Yan,Yiwen Cheng,Li Shao,Xia Liu,Ruilai Jiang,Shaochang Wu

评论