EMBO R:营养物质和肠道菌群如何影响肝脏生物钟
  • 营养物质的改变可通过调节特定的转录通路而将肝脏生物钟重编程;
  • 分析肠道菌群是否影响了生理节律的稳态及其如何远程控制肝脏生物钟;
  • 在高脂饮食下,肠道菌群引起肝脏内PPAR-γ介导的振荡性转录活化;
  • 抗生素处理抑制了肝脏内PPAR-γ诱导的转录;
  • 肠道菌群通过调节肝脏代谢过程中的转录过程影响肝脏生物钟。
主编推荐语
蓝灿辉 | 热心肠先生
关于生物钟的相关文献,MC系统前一阵子推荐了一些,今天EMBO子刊这篇,对营养物质和肠道菌群如何影响肝脏生物钟,作了机制上的研究,推荐看一看。
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EMBO Reports [IF:7.497]

Gut microbiota directs PPARγ-driven reprogramming of the liver circadian clock by nutritional challenge

饮食中营养物质改变后肠道菌群引起PPAR-γ诱导的肝脏生物钟重编程

10.15252/embr.201642463

2016-07-14, Article

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The liver circadian clock is reprogrammed by nutritional challenge through the rewiring of specific transcriptional pathways. As the gut microbiota is tightly connected to host metabolism, whose coordination is governed by the circadian clock, we explored whether gut microbes influence circadian homeostasis and how they distally control the peripheral clock in the liver. Using fecal transplant procedures we reveal that, in response to high-fat diet, the gut microbiota drives PPARγ-mediated activation of newly oscillatory transcriptional programs in the liver. Moreover, antibiotics treatment prevents PPARγ-driven transcription in the liver, underscoring the essential role of gut microbes in clock reprogramming and hepatic circadian homeostasis. Thus, a specific molecular signature characterizes the influence of the gut microbiome in the liver, leading to the transcriptional rewiring of hepatic metabolism.

First Authors:
Mari Murakami

Correspondence Authors:
Paolo Sassone-Corsi

All Authors:
Mari Murakami,Paola Tognini,Yu Liu,Kristin L Eckel-Mahan,Pierre Baldi,Paolo Sassone-Corsi

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