婴儿喂养方式和生命第一年体重增长模式影响未来肥胖风险
创作:Epi汪 审核:Epi汪 2020年08月07日
  • 纳入两项纵向队列儿童的数据,记录喂养方式和一年内体重身高增长情况;
  • 根据身高体重变化轨迹,将婴儿分为快速增长型、正常型和慢速增长型;
  • 无论是母乳喂养还是配方奶粉喂养,婴儿体重快速增长型均占41%左右;
  • 婴儿喂养方式和婴儿早期体重增长模式具有明显的交互作用,配方奶粉+体重快速增长型婴儿在1岁时诊断为超重的风险高于母乳喂养+正常增长型婴儿;
  • 但是母乳喂养+体重快速增长型婴儿超重/肥胖的风险并未增加。
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Epi汪
本研究通过队列数据分析发现,婴儿喂养方式和体重增长模式之间存在交互作用,配方奶粉喂养且体重快速增长的儿童,未来肥胖的风险增高。本研究提示采用配方奶粉喂养新生儿时应注意其体重的变化。
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Impact of early rapid weight gain on odds for overweight at one year differs between breastfed and formula‐fed infants

母乳喂养和配方奶粉喂养方式下婴儿早期体重快速增长与一周岁儿童肥胖风险的关联

10.1111/ijpo.12688

2020-07-23, Article

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Background: Early rapid weight gain (RWG) increases, whereas longer durations of breastfeeding decreases, odds for later obesity.
Objectives: To determine the independent and interactive effects of early weight gain and diet on infant weight status trajectories and odds for overweight at 1 year.
Methods: We conducted secondary analysis on data from two longitudinal trials with repeated anthropometric measures. One trial consisted of predominantly or exclusively breastfed (BF, n = 97) infants, whereas the other consisted of exclusively formula‐fed (FF, n = 113) infants. Weight‐for‐length z‐score (WLZ) change from 0.5 to 4.5 months was used to categorize early weight gain as slow (<−0.67; SWG), normal (−0.67 to 0.67; NWG) or rapid (>0.67; RWG). Linear‐mixed effects models were fit to examine the independent effects and interaction of early diet (BF, FF) and weight gain (SWG, NWG, RWG) groups on WLZ trajectories; logistic regression was used to assess odds for overweight at 1 year.
Results: While similar percentages (41%) of BF and FF infants experienced RWG, we found a significant diet × early weight gain group interaction (P  < .001) on weight status. At 1 year, the WLZ of FF infants with RWG (1.57 ± 0.99) was twice that of BF infants with RWG (0.83 ± 0.92). Using BF infants with NWG as the reference group, FF infants with RWG had increased odds [OR: 25.3 (95% CI: 3.21, 199.7)] for overweight at 1 year, whereas BF infants with RWG did not.
Conclusions: Early diet interacts with early weight gain and influences weight status trajectories and overweight risk at 1 year.

First Authors:
Jillian C Trabulsi

Correspondence Authors:
Jillian C Trabulsi

All Authors:
Jillian C Trabulsi,Alissa D Smethers,Jessica R Eosso,Mia A Papas,Virginia A Stallings,Julie A Mennella

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