夜间光照与节律紊乱影响胰腺癌风险
创作:Lexi 审核:Lexi 02月06日
  • 从NIH-AARP(美国退休人员协会)饮食和健康研究中纳入超过46万名参与者,对夜间光照(LAN)和胰腺导管癌(PDAC)进行关联性研究;
  • 随访时间长达16.2年,队列中共发现2502例PDAC事件;
  • 研究发现较高的LAN暴露与PDAC风险升高相关;
  • 相比LAN最低的四分之一人群,LAN最高的四分之一人群的PDAC风险增加27%(HR,1.24),且与性别无关;
  • 相比肥胖组,正常组和超重组中LAN与PDAC的相关性更强。
主编推荐语
Lexi
昼夜节律受干扰可能影响癌症发生。最近的研究表明,夜间光照(LAN)是一种昼夜节律干扰物,可能是癌症的风险因素。此外,LAN还与肥胖与糖尿病有关,而这两种疾病也是胰腺导管癌(PDAC)的危险因素。最新发表在Cancer Research的研究支持LAN和昼夜节律打乱可能是PDAC危险因素的假设。
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Cancer Research [IF:9.727]

Light at Night and Risk of Pancreatic Cancer in the NIH-AARP Diet and Health Study

在NIH-AARP饮食和健康研究中,夜间光照与胰腺癌风险的关系

10.1158/0008-5472.CAN-20-2256

01-29, Article

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Circadian disruption may play a role in carcinogenesis. Recent research suggests that light at night (LAN), a circadian disruptor, may be a risk factor for cancer. Moreover, LAN has been linked to obesity and diabetes, two risk factors for pancreatic ductal adenocarcinoma (PDAC). Here we examine the relationship between LAN and PDAC in an epidemiological study of 464,371 participants from the NIH-AARP Diet and Health Study. LAN was estimated from satellite imagery at baseline (1996) and incident primary PDAC cases were ascertained from state cancer registries. Cox proportional hazards models were used to estimate hazard ratios (HR) and 2-sided 95% confidence intervals (CI) for the association between quintiles of LAN and PDAC in the overall population stratified by sex. Over up to 16.2 years of follow-up, a total of 2,502 incident PDAC were identified in the cohort. Higher estimated LAN exposure was associated with an elevated PDAC risk. Compared to those living in areas in the lowest LAN quintile, those in areas in the highest quintile had a 27% increase PDAC risk (HR (95% CI), 1.24 (1.03, 1.49)), with similar risk for men (1.21 (0.96, 1.53)) and women (1.28 (0.94, 1.75)). In addition, stronger associations were observed in normal and overweight groups compared to the obese group (p for interaction = 0.03). Our results support the hypothesis that LAN and circadian disruption may be risk factors for PDAC.

First Authors:
Qian Xiao

Correspondence Authors:
Qian Xiao

All Authors:
Qian Xiao,Rena R Jones,Peter James,Rachael Z Stolzenberg-Solomon

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