Nature子刊:减肥手术调控血糖的机制
创作:吴芹 审核:szx 01月08日
  • 大鼠和人胃中有GLP-1阳性细胞,这些细胞共同表达饥饿素或生长抑素;
  • 大鼠体内的GLP-1阳性细胞可分泌活性GLP-1;
  • 胃葡萄糖负荷可诱导瘦削大鼠(而非高脂饮食喂养大鼠)的胃和门静脉中的GLP-1水平快速升高,但高脂饮食喂养大鼠接受垂直袖状胃切除术(VSG)后可恢复;
  • 接受VSG或及Roux-en-Y胃旁路术的肥胖患者及肥胖大鼠表现出新的胃粘膜表型,颈黏液细胞增生,同时GLP-1阳性细胞密度增加,促进循环GLP-1水平升高。
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Nature Communications上发表的一项最新研究,发现减肥手术可通过增加大鼠胃粘膜中的GLP-1阳性细胞,并促进这些细胞分泌活性GLP-1,从而起到调控血糖的作用。另外,在接受了减肥手术的肥胖患者中,可观察到胃粘膜GLP-1阳性细胞的增加。
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Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

减肥手术诱导一种功能性GLP-1表达细胞增加的新胃粘膜表型

10.1038/s41467-020-20301-1

01-04, Article

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Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.

First Authors:
Lara Ribeiro-Parenti,Anne Charlotte Jarry

Correspondence Authors:
Maude Le Gall,Andre Bado

All Authors:
Lara Ribeiro-Parenti,Anne Charlotte Jarry,Jean-Baptiste Cavin,Alexandra Willemetz,Johanne Le Beyec,Aurélie Sannier,Samira Benadda,Anne-Laure Pelletier,Muriel Hourseau,Thibaut Léger,Bastien Morlet,Anne Couvelard,Younes Anini,Simon Msika,Jean-Pierre Marmuse,Sévérine Ledoux,Maude Le Gall,Andre Bado

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