Nature子刊：减肥手术调控血糖的机制
- ①大鼠和人胃中有GLP-1阳性细胞，这些细胞共同表达饥饿素或生长抑素；
- ②大鼠体内的GLP-1阳性细胞可分泌活性GLP-1；
- ③胃葡萄糖负荷可诱导瘦削大鼠（而非高脂饮食喂养大鼠）的胃和门静脉中的GLP-1水平快速升高，但高脂饮食喂养大鼠接受垂直袖状胃切除术（VSG）后可恢复；
- ④接受VSG或及Roux-en-Y胃旁路术的肥胖患者及肥胖大鼠表现出新的胃粘膜表型，颈黏液细胞增生，同时GLP-1阳性细胞密度增加，促进循环GLP-1水平升高。
主编推荐语
Nature Communications上发表的一项最新研究，发现减肥手术可通过增加大鼠胃粘膜中的GLP-1阳性细胞，并促进这些细胞分泌活性GLP-1，从而起到调控血糖的作用。另外，在接受了减肥手术的肥胖患者中，可观察到胃粘膜GLP-1阳性细胞的增加。
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Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells
减肥手术诱导一种功能性GLP-1表达细胞增加的新胃粘膜表型
10.1038/s41467-020-20301-1
01-04, Article
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Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.
First Authors:
Lara Ribeiro-Parenti,Anne Charlotte Jarry
Correspondence Authors:
Maude Le Gall,Andre Bado
All Authors:
Lara Ribeiro-Parenti,Anne Charlotte Jarry,Jean-Baptiste Cavin,Alexandra Willemetz,Johanne Le Beyec,Aurélie Sannier,Samira Benadda,Anne-Laure Pelletier,Muriel Hourseau,Thibaut Léger,Bastien Morlet,Anne Couvelard,Younes Anini,Simon Msika,Jean-Pierre Marmuse,Sévérine Ledoux,Maude Le Gall,Andre Bado
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