Nature子刊:领域大牛解读益生菌与益生菌研究
  • 益生菌研究的局限性包括临床试验数据缺乏规范性,菌株间的差异性,被试个体差异性及资助方的利益干扰;
  • 益生菌对急性肠胃炎、艰难梭菌腹泻、IBS、新生儿败血症以及急性呼吸道感染等有益处;
  • 活性机制包括免疫调节、抵抗致病菌、改善肠屏障功能等, 但缺乏体内实验,未考量微生物间及宿主-微生物互作;
  • 提高益生菌功效需克服宿主菌群的定植抗性,开发疾病或人群特异性的干预方案,并开展无商业利益相关的大规模随机双盲临床试验。
主编推荐语
小肠君
益生菌产品广受欢迎,但是益生菌的功效却无定论。《Nature Medicine》近期发表了以色列魏茨曼科学研究院两位益生菌和肠道菌群领域专家的观点文章,介绍了目前益生菌研究的进展、挑战和发展方向,指出需重视益生菌研究的方法学以及规范化,值得参考。
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Nature Medicine [IF:87.241]

The pros, cons, and many unknowns of probiotics

关于益生菌的优点、缺点和未知

10.1038/s41591-019-0439-x

2019-05-06, Article

Abstract & Authors:展开

Abstract:收起
Consumption of over-the-counter probiotics for promotion of health and well-being has increased worldwide in recent years. However, although probiotic use has been greatly popularized among the general public, there are conflicting clinical results for many probiotic strains and formulations. Emerging insights from microbiome research enable an assessment of gut colonization by probiotics, strain-level activity, interactions with the indigenous microbiome, safety and impacts on the host, and allow the association of probiotics with physiological effects and potentially useful medical indications. In this Perspective, we highlight key advances, challenges and limitations in striving toward an unbiased interpretation of the large amount of data regarding over-the-counter probiotics, and propose avenues to improve the quality of evidence, transparency, public awareness and regulation of their use.

First Authors:
Jotham Suez,Niv Zmora

Correspondence Authors:
Eran Segal,Eran Elinav

All Authors:
Jotham Suez,Niv Zmora,Eran Segal,Eran Elinav

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