围产期因素与后代肠道菌群健康(综述)
创作:Mona 审核:mildbreeze 2020年08月26日
  • 母体营养、抗生素使用、出生胎龄、分娩方式、母乳喂养及母体应激等围产期因素,可通过影响胎儿生长以及母体和后代生命早期的肠道菌群,对后代健康造成长久影响;
  • 生命早期肠道菌群包括细菌、真菌、病毒/噬菌体等,存在一定的发展变化规律,母体粪便、阴道和母乳的菌群是后代肠道细菌的重要来源;
  • 生命早期肠道菌群与免疫发育、过敏风险、糖尿病、肥胖等有关,一些益生菌干预或可改善婴儿健康。
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mildbreeze
围产期因素可通过调节母亲和婴儿的肠道菌群,影响后代的长期健康。FEMS Microbiology Reviews发表的综述文章,介绍了产前、分娩和产后的多种关键围产期因素、生命早期的肠道菌群发育特征和来源,以及这些因素对后代肠道菌群和健康的短期和长期影响。
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A good start in life is important–perinatal factors dictate early microbiota development and longer-term maturation

生命的良好开端是重要的——围产期因素决定菌群的早期发育和长期成熟

10.1093/femsre/fuaa030

2020-08-21, Article

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Maternal health status is vital for the development of the offspring of humans including physiological health and psychological functions. The complex and diverse microbial ecosystem residing within humans contributes critically to these intergenerational impacts. Perinatal factors including maternal nutrition, antibiotic use, and maternal stress alter the maternal gut microbiota during pregnancy, which can be transmitted to the offspring. In addition, gestational age at birth and mode of delivery are indicated frequently to modulate the acquisition and development of gut microbiota in early life. The early-life gut microbiota engages in a range of host biological processes, particularly immunity, cognitive neurodevelopment, and metabolism. The perturbed early-life gut microbiota increases the risk for disease in early and later life, highlighting the importance of understanding relationships of perinatal factors with early-life microbial composition and functions. In this review, we present an overview of the crucial perinatal factors and summarise updated knowledge of early-life microbiota, as well as how the perinatal factors shape gut microbiota at short- and long-term. We further discuss the clinical consequences of perturbations of early-life gut microbiota and potential therapeutic interventions with probiotics/live biotherapeutics.

First Authors:
Shaopu Wang,Muireann Egan

Correspondence Authors:
Catherine Stanton

All Authors:
Shaopu Wang,Muireann Egan,C Anthony Ryan,Patrick Boyaval,Eugene M Dempsey,R Paul Ross,Catherine Stanton

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