生酮饮食或对放疗期乳腺癌患者有益
创作:楸楸 审核:nana 03月08日
  • 纳入59名接受放射治疗的早期乳腺癌女性患者,其中29人接受生酮饮食(KD),另外30名患者接受标准饮食(SD);
  • 与SD相比,KD组患者在情绪功能、社交功能和睡眠质量等方面均得到了显著改善,且KD组全身治疗副作用较小;
  • 两组患者乳腺癌症状均明显加重,但KD组的加重并不明显;
  • KD组肝或肾功能无损害,且表征代谢健康的生物标志物,如γ-谷氨酰转肽酶、肌酐、甘油三酸酯、胰岛素样生长因子-1和游离三碘甲状腺原氨酸等均显著改善。
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nana
生酮饮食(KD)已被建议作为癌症患者的补充营养治疗,了解生酮饮食在癌症治疗期间的安全性十分重要,Clinical Nutrition最近发表的文章,研究了生酮饮食对接受放疗的早期乳腺癌妇女的生活质量和血液参数的影响,结果表明放疗期间生酮饮食对乳腺癌患者是安全的,并能改善患者生活质量和代谢健康。
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A ketogenic diet consumed during radiotherapy improves several aspects of quality of life and metabolic health in women with breast cancer

放射治疗期间生酮饮食可多方面改善乳腺癌女性患者的生活质量和代谢健康

10.1016/j.clnu.2021.01.023

01-26, Article

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Background & aims: Ketogenic diets (KDs) have been proposed as complementary nutritional treatments for cancer patients. Because it is important to gain knowledge about the safety of KDs adopted during cancer therapy, we studied the effects of KDs on quality of life and blood parameters in women with early-stage breast cancer undergoing radiotherapy.
Methods: A total of 29 patients consuming a KD were compared to 30 patients consuming their standard diet (SD) with respect to EORTC-QLQ30 questionnaire scores and different metabolic and hormonal blood parameters that were obtained prior to, in the middle of and at the end of radiotherapy. Baseline-to-end differences were assessed using Wilcoxon tests, and longitudinal changes were analyzed using linear mixed effects models.
Results: Compared to the SD, women consuming a KD experienced significant improvements in emotional functioning, social functioning, sleep quality, future perspectives and systemic therapy side effects (all p-values <0.01). While breast symptoms increased significantly in both groups, the increase was less pronounced in the KD group. There was no hint of a detrimental effect of the KDs on either liver or kidney function; in contrast, biomarkers of metabolic health (gamma-glutamyl-transpeptidase, creatinine, triglycerides, IGF-1, free T3) significantly improved in the KD, but not the SD group.
Conclusions: These data support the hypothesis that consuming a KD during radiotherapy is safe for women with breast cancer and has the potential to improve quality of life and metabolic health.

First Authors:
Rainer J Klement

Correspondence Authors:
Rainer J Klement

All Authors:
Rainer J Klement,Michael M Weigel,Reinhart A Sweeney

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