抵御病原体入侵,免疫系统的作用不容忽视
创作:fang fang 审核:周旸 2019年02月12日
  • 共生细菌是保护宿主免受病原体侵害的关键因素,但感染的结果由病原体、共生菌和免疫系统相互作用决定;
  • 利用免疫共生菌模型研究发现,清除病原体需要宿主免疫系统与共生菌的协同作用;
  • 目前的菌群互作模型忽略了免疫系统的作用,亟需建立纳入免疫反应的数学模型,从而更好地理解感染动态;
  • 当菌群状态或宿主免疫低于临界水平时,病原体可增殖并持续感染;
  • 整合了免疫与共生菌的模型,有助于提出针对感染的更有效的靶向治疗方法。
主编推荐语
周旸
宿主免疫系统在抵御病原体入侵中的作用不可忽视。本文作者利用简单的宿主内环境分析模型,发现抵御病原体入侵需要免疫系统与共生菌群协同作用,强调了在研究病原菌入侵时,不能只关注于共生菌-病原菌互作,亟需建立考虑了免疫反应的研究模型。
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Not by (Good) Microbes Alone: Towards Immunocommensal Therapies

并非(好)菌群独自作用:走向免疫共生菌疗法

10.1016/j.tim.2018.12.006

2019-01-14, Review

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Abstract:收起
Commensal bacteria have been identified as critical drivers of host resilience to pathogen invasion. The resulting ‘competitive exclusion’ of pathogens by commensals can arise via multiple mechanisms, including direct competition for sites of colonization, production of metabolic products that inhibit pathogen growth, and modulation of host immune responses (including differential targeting of pathogens). Nonetheless, suppression of pathogens through the combined action of commensals and host immunity is far from inevitable. Here, we utilize a simple, within-host ecosystem model to explore the microbiological and immunological conditions that govern the fate of pathogen colonization. Model analysis leads to the hypothesis that robust elimination of pathogens requires a synergy between host immune defense and commensal bacteria. That is, pathogens can proliferate and establish persistent infections if either the state of the microbiota or the host immune defense falls below critical levels. Leveraging these findings, we advocate for improved integration of nonlinear dynamic models in efforts to understand infection dynamics in an immunological context. Doing so may provide new opportunities to establish baseline indicators for healthy microbiomes and to develop improved therapeutics through targeted modification of feedback amongst commensals and between commensals and the immune system.

First Authors:
Chung-Yin Leung

Correspondence Authors:
Chung-Yin Leung,Joshua S Weitz

All Authors:
Chung-Yin Leung,Joshua S Weitz

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