西安交大:运动或可通过肠脑轴改善高血压
创作:周云燕 审核:兵兵 02月04日
  • 与久坐高血压大鼠相比,经过12周中等强度运动的高血压大鼠的收缩压降低;
  • 该现象与肠道菌群的β多样性改变、α多样性和有益菌增加、激活的小胶质细胞数量和神经炎症减少、肠道病理、炎症和通透性的改善有关;
  • 运动对高血压大鼠的有益影响在4周训练中断后依然存在;
  • 久坐高血压大鼠移植来自经过运动训练的高血压大鼠的粪菌后,收缩压降低,肠道菌群改变,肠脑轴功能改善;
  • 运动对高血压有益,能够重塑肠道菌群,改善功能失调的肠脑轴。
主编推荐语
兵兵
西安交通大学基础医学院康玉明和李宏宝团队研究成果。研究发现,与久坐的高血压小鼠相比,进行运动训练的小鼠的收缩压降低。并且,在此过程中,小鼠的肠道菌群改变、有益菌增加、脑小胶质细胞数量和神经炎症减少等。粪菌移植也证实了运动带来的降血压益处确实与肠道菌群有关。该研究初步表明,运动可以通过干预肠脑轴缓解高血压。
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Gut Microbes [IF:7.74]

Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat

运动通过重塑肠道菌群和改善肠脑轴降低自发性高血压大鼠的血压

10.1080/19490976.2020.1854642

2020-12-31, Article

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Exercise (Ex) has long been recognized to produce beneficial effects on hypertension (HTN). This coupled with evidence of gut dysbiosis and an impaired gut-brain axis led us to hypothesize that reshaping of gut microbiota and improvement in impaired gut-brain axis would, in part, be associated with beneficial influence of exercise. Male spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats were randomized into sedentary, trained, and detrained groups. Trained rats underwent moderate-intensity exercise for 12 weeks, whereas, detrained groups underwent 8 weeks of moderate-intensity exercise followed by 4 weeks of detraining. Fecal microbiota, gut pathology, intestinal inflammation, and permeability, brain microglia and neuroinflammation were analyzed. We observed that exercise training resulted in a persistent decrease in systolic blood pressure in the SHR. This was associated with increase in microbial α diversity, altered β diversity, and enrichment of beneficial bacterial genera. Furthermore, decrease in the number of activated microglia, neuroinflammation in the hypothalamic paraventricular nucleus, improved gut pathology, inflammation, and permeability were also observed in the SHR following exercise. Interestingly, short-term detraining did not abolish these exercise-mediated improvements. Finally, fecal microbiota transplantation from exercised SHR into sedentary SHR resulted in attenuated SBP and an improved gut-brain axis. These observations support our concept that an impaired gut-brain axis is linked to HTN and exercise ameliorates this impairment to induce antihypertensive effects.

First Authors:
Wen-Jie Xia,Meng-Lu Xu,Xiao-Jing Yu

Correspondence Authors:
Hong-Bao Li,Yu-Ming Kang

All Authors:
Wen-Jie Xia,Meng-Lu Xu,Xiao-Jing Yu,Meng-Meng Du,Xu-Hui Li,Tao Yang,Lu Li,Ying Li,Kai B Kang,Qing Su,Jia-Xi Xu,Xiao-Lian Shi,Xiao-Min Wang,Hong-Bao Li,Yu-Ming Kang

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