饮食质量如何影响人结肠粘膜菌群
  • 纳入34名中老年受试者,分析HEI饮食质量评分与结肠粘膜菌群的关联;
  • 饮食总质量、水果、奶制品和大豆饮品(HEI7)、饱和脂肪/酒/添加糖(HEI12)等的饮食质量,对菌群组成的影响最大;
  • 饮食质量低:副拟杆菌、罗斯拜瑞氏菌和Subdoligranulum(S)菌属减少、梭杆菌属增多;
  • 整果饮食质量低:罗斯拜瑞氏菌减少、拟杆菌属增加;
  • HEI7分数低:栖粪杆菌和梭杆菌属减少、拟杆菌属增加;
  • HEI12分数低:S菌属减少、埃希氏菌和梭杆菌属增加。
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饮食如何影响肠道菌群?大部分相关研究都以粪便菌群为样本,鲜有对肠粘膜菌群的分析。《American Journal of Clinical Nutrition》近期发表来自美国贝勒医学院华人学者Li Jiao团队的研究,在34名无肠道疾病的中老年受试者中,分析了反映饮食质量的健康饮食指数(HEI)-2005评分与结肠粘膜菌群的关联,发现饮食质量较低的人,其菌群中潜在的有益菌减少、有害菌增多,表明饮食质量或通过改变肠粘膜菌群的结构和多样性,来影响特定疾病风险。
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Dietary quality and the colonic mucosa–associated gut microbiome in humans

饮食质量与人结肠粘膜相关肠道菌群

10.1093/ajcn/nqz139

2019-07-10, Article

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Background: Despite tremendous interest in modulating the microbiome to improve health, the association between diet and the colonic mucosa–associated gut microbiome in healthy individuals has not been examined.
Objective: To investigate the associations between Healthy Eating Index (HEI)–2005 and the colonic mucosa–associated microbiota.
Methods: In this cross-sectional observational study, we analyzed bacterial community composition and structure using 16S rRNA gene (V4 region) sequencing of 97 colonic mucosal biopsies obtained endoscopically from different colon segments of 34 polyp-free participants. Dietary consumption was ascertained using an FFQ. Differences in α- and β-diversity and taxonomic relative abundances between the higher and lower score of total HEI and its components were compared, followed by multivariable analyses.
Results: The structure of the microbiota significantly differed by the scores for total HEI, total and whole fruits (HEI 1 and HEI 2), whole grains (HEI 6), milk products and soy beverages (HEI 7), and solid fat, alcohol, and added sugar (HEI 12). A lower score for total HEI and HEIs 2, 7, and 12 was associated with significantly lower richness. A lower score for total HEI was associated with significantly reduced relative abundance of Parabacteroides, Roseburia, and Subdoligranulum but higher Fusobacterium. A lower score for HEI 2 was associated with lower Roseburia but higher Bacteroides. A lower score for HEI 7 was associated with lower Faecalibacterium and Fusobacterium but higher Bacteroides. A lower score for HEI 12 was associated with lower Subdoligranulum but higher Escherichia and Fusobacterium (false discovery rate–adjusted P values <0.05). The findings were confirmed by multivariate analysis. Less abundant bacteria such as Alistipes, Odoribacter, Bilophila, and Tyzzerella were also associated with dietary quality.
Conclusions: A lower score for total HEI–2005 was significantly associated with reduced relative abundance of potentially beneficial bacteria but increased potentially harmful bacteria in the colonic mucosa of endoscopically normal individuals.

First Authors:
Yanhong Liu

Correspondence Authors:
Li Jiao

All Authors:
Yanhong Liu,Nadim J Ajami,Hashem B El-Serag,Clark Hair,David Y Graham,Donna L White,Liang Chen,Zhensheng Wang,Sarah Plew,Jennifer Kramer,Rhonda Cole,Ruben Hernaez,Jason Hou,Nisreen Husain,Maria E Jarbrink-Sehgal,Fasiha Kanwal,Gyanprakash Ketwaroo,Yamini Natarajan,Rajesh Shah,Maria Velez,Niharika Mallepally,Joseph F Petrosino,Li Jiao

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