早发性大肠癌有哪些风险因素
  • 纳入20项研究进行荟萃分析(涉及47,692例早发性结直肠癌),总结早发性结直肠癌的非遗传风险因素;
  • 显著的风险因素包括:直系亲属的结直肠癌史(RR=4.21)、高脂血症(RR=1.62)、肥胖(RR=1.54)和饮酒(RR=1.71);
  • 虽然吸烟被认为是风险因素之一,但其与早发性结直肠癌风险的关联并不显著;
  • 其它潜在风险因素包括:高血压、代谢综合征、溃疡性结肠炎、慢性肾病、饮食因素、久坐行为和有机粉尘职业暴露,但相关研究较少。
主编推荐语
szx
Clinical Gastroenterology and Hepatology上发表的一项荟萃分析结果,对20项研究的数据进行总结后发现,早发性结直肠癌的非遗传风险因素包括:直系亲属的结直肠癌病史、高脂血症、肥胖及饮酒。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Risk factors for early-onset colorectal cancer: A systematic review and meta-analysis

早发性结直肠癌的风险因素:系统回顾与荟萃分析

10.1016/j.cgh.2021.01.037

01-28, Article

Abstract & Authors:展开

Abstract:收起
Background & Aims: Despite the widespread increase in the incidence of early-onset colorectal cancer (EoCRC), the reasons for this increase remain unclear. The objective of this study was to determine risk factors for the development of EoCRC.
Methods: We conducted a systematic literature review and meta-analysis of studies examining non-genetic risk factors for EoCRC, including demographic factors, comorbidities, and lifestyle factors. Random effects meta-analyses were conducted for risk factors that were examined in at least three studies. Heterogeneity was investigated using the Q-test and I 2 statistic.
Results: From 3304 initial citations, 20 studies were included in this review. Significant risk factors for EoCRC included CRC history in a first-degree relative (RR 4.21, 95% CI 2.61-6.79), hyperlipidemia (RR 1.62, 95% CI 1.22-2.13), obesity (RR 1.54, 95% CI 1.01-2.35), and alcohol consumption (high vs. non-drinkers) (RR 1.71, 95% CI 1.62-1.80). While smoking was suggestive as a risk factor, the association was not statistically significant (RR 1.35, 95% CI 0.81-2.25). With the exception of alcohol consumption, there was considerable heterogeneity among studies (I 2 > 60%). Other potential risk factors included hypertension, metabolic syndrome, ulcerative colitis, chronic kidney disease, dietary factors, sedentary behaviour, and occupational exposure to organic dusts, but these were only examined in one or two studies.
Conclusions: The results of this study advance the understanding of the etiology of EoCRC. High-quality studies conducted on generalizable populations and that comprehensively examine risk factors for EoCRC are required to inform primary and secondary prevention strategies.

First Authors:
Dylan E O'Sullivan

Correspondence Authors:
Darren R Brenner

All Authors:
Dylan E O'Sullivan,R Liam Sutherland,Susanna Town,Kristian Chow,Jeremy Fan,Nauzer Forbes,Steven J Heitman,Robert J Hilsden,Darren R Brenner

评论