肠道菌群失调相关标志物或可诊断精神疾病及慢性疲劳(综述)
创作:szx 审核:szx 02月18日
  • 纳入19项研究(共涉及2758名患者及1847名健康对照)进行荟萃分析,总结严重精神疾病及慢性疲劳患者的肠道菌群失调标志物的变化;
  • 与对照相比,双相障碍及抑郁患者的连蛋白及sCD14的水平升高,慢性疲劳及抑郁患者的LPS及LPS结合蛋白的水平升高,双相障碍、抑郁、精神分裂症及慢性疲劳患者的抗内毒素抗体的水平升高,双相障碍、抑郁及精神分裂症患者的α1-抗胰蛋白酶的水平升高;
  • 肠道菌群失调标志物的水平与疾病行为的严重程度相关。
主编推荐语
szx
Molecular Psychiatry上发表的一项荟萃分析结果,对19项研究的数据进行总结后发现,严重精神疾病(包括抑郁、双相障碍、精神分裂症)及慢性疲劳患者的多种肠道菌群失调相关生物标志物(包括连蛋白、sCD14、LPS、LPS结合蛋白、抗内毒素抗体、α1-抗胰蛋白酶)的水平显著高于对照。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis

严重精神疾病及慢性疲劳患者的肠道菌群失调:系统性综述与荟萃分析

10.1038/s41380-021-01032-1

02-08, Review

Abstract & Authors:展开

Abstract:收起
Reduced gut-microbial diversity (“gut dysbiosis”) has been associated with an anhedonic/amotivational syndrome (“sickness behavior”) that manifests across severe mental disorders and represent the key clinical feature of chronic fatigue. In this systematic review and meta-analysis, we investigated differences in proxy biomarkers of gut dysbiosis in patients with severe mental illness and chronic fatigue vs. controls and the association of these biomarkers with sickness behavior across diagnostic categories. Following PRISMA guidelines, we searched from inception to April 2020 for all the studies investigating proxy biomarkers of gut dysbiosis in patients with severe mental illness and chronic fatigue. Data were independently extracted by multiple observers, and a random-mixed model was used for the analysis. Heterogeneity was assessed with the I2 index. Thirty-three studies were included in the systematic review; nineteen in the meta-analysis (N = 2758 patients and N = 1847 healthy controls). When compared to controls, patients showed increased levels of zonulin (four studies reporting data on bipolar disorder and depression, SMD = 0.97; 95% Cl = 0.10–1.85; P = 0.03, I2 = 86.61%), lipopolysaccharide (two studies reporting data on chronic fatigue and depression, SMD = 0.77; 95% Cl = 0.42–1.12; P < 0.01; I2 = 0%), antibodies against endotoxin (seven studies reporting data on bipolar disorder, depression, schizophrenia, and chronic fatigue, SMD = 0.99; 95% CI = 0.27–1.70; P < 0.01, I2 = 97.14%), sCD14 (six studies reporting data on bipolar disorder, depression, schizophrenia, and chronic fatigue, SMD = 0.54; 95% Cl 0.16–0.81; P < 0.01, I2 = 90.68%), LBP (LBP, two studies reporting data on chronic fatigue and depression, SMD = 0.87; 95% Cl = 0.25–1.48; P < 0.01; I2 = 56.80%), alpha-1-antitripsin (six studies reporting data on bipolar disorder, depression, and schizophrenia, SMD = 1.23; 95% Cl = 0.57–1.88; P < 0.01, I2: 89.25%). Elevated levels of gut dysbiosis markers positively correlated with severity of sickness behavior in patients with severe mental illness and chronic fatigue. Our findings suggest that gut dysbiosis may underlie symptoms of sickness behavior across traditional diagnostic boundaries. Future investigations should validate these findings comparing the performances of the trans-diagnostic vs. categorical approach. This will facilitate treatment breakthrough in an area of unmet clinical need.

First Authors:
Jenelle Marcelle Safadi

Correspondence Authors:
Amedeo Minichino

All Authors:
Jenelle Marcelle Safadi,Alice M G Quinton,Belinda R Lennox,Philip W J Burnet,Amedeo Minichino

评论