焦虑及抑郁患者的肠道菌群变化
创作:szx 审核:szx 2020年12月10日
  • 纳入26项研究,总结焦虑及抑郁与肠道菌群的关联;
  • 17项研究对比抑郁症患者与对照,2项研究对比广泛性焦虑障碍(GAD)患者与对照,1项研究对比抑郁、焦虑或抑郁+焦虑患者与对照;
  • 肠道菌群的α-多样性及β-多样性与焦虑及抑郁的关联在不同研究中结果并不一致;
  • 肠杆菌科、脱硫弧菌属等促炎症细菌分类群的较高丰度、短链脂肪酸产生菌的较低丰度与焦虑及抑郁相关;
  • 部分细菌分类群可能通过将外周炎症传递入脑,与焦虑及抑郁产生因果关联。
主编推荐语
szx
Clinical Psychology Review上发表的一篇系统性综述,通过对26项研究(包括20项病例-对照研究)进行总结,分析肠道菌群变化与焦虑及抑郁的关联,发现在焦虑及抑郁患者的肠道菌群中,促炎症菌富集,而短链脂肪酸产生菌减少。机制上,特定细菌可能通过肠-脑轴将外周炎症传递入脑,在焦虑及抑郁的发病机制中起重要作用。
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The gut microbiota in anxiety and depression – A systematic review

焦虑及抑郁患者的肠道菌群——系统性综述

10.1016/j.cpr.2020.101943

2020-11-29, Review

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Growing evidence indicates the community of microorganisms throughout the gastrointestinal tract, (i.e., gut microbiota), is associated with anxiety and depressive disorders. We present the first systematic review of the gut microbiota in anxiety disorders, along with an update in depression. Consideration of shared underlying features is essential due to the high rates of comorbidity. Systematic searches, following PRISMA guidelines, identified 26 studies (two case-control comparisons of the gut microbiota in generalised anxiety disorder, 17 in depression, one incorporating both anxiety/depression, and five including symptom-only measures). Alpha and beta diversity findings were inconsistent; however, differences in bacterial taxa indicated disorders may be characterised by a higher abundance of proinflammatory species (e.g., Enterobacteriaceae and Desulfovibrio), and lower short-chain fatty acid producing-bacteria (e.g., Faecalibacterium). Several taxa, and their mechanisms of action, may relate to anxiety and depression pathophysiology via communication of peripheral inflammation to the brain. Although the gut microbiota remains a promising target for prevention and therapy, future research should assess confounders, particularly diet and psychotropic medications, and should examine microorganism function.

First Authors:
Carra A Simpson

Correspondence Authors:
Carra A Simpson

All Authors:
Carra A Simpson,Carmela Diaz-Arteche,Djamila Eliby,Orli S Schwartz,Julian G Simmons,Caitlin SM Cowan

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