Cell子刊:微生物组与癌症(一图+一文读懂)
  • 微生物组存在于粘膜表面以及不同癌症的低生物量生态系统中,多组学大数据分析有助于理解微生物组与癌症的关系;
  • 癌症相关的微生物(细菌、病毒、真菌、寄生虫)及群落失调,可能促进癌症的发生发展;
  • 其机制包括:接触依赖性互作(与宿主细胞直接互作)、非接触依赖性互作(从远端释放促癌分子和外膜囊泡)以及调节免疫微环境等;
  • 微生物组可用于癌症诊断和患者分层,也可影响治疗反应,通过多种方式调节微生物组或能改善癌症治疗。
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mildbreeze
Cancer Cell近期发表长综述,详细介绍了微生物组与癌症的相关研究进展,总结并列举了微生物相关的促癌分子机制,探讨了微生物组在癌症诊断和治疗方面的应用前景,以及目前该研究领域中所面临的重要挑战,非常值得阅读和学习。我们特别将文中的配图编译为一图读懂,希望能助你长知识。
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Cancer Cell [IF:38.585]

Microbiome and cancer

微生物组和癌症

10.1016/j.ccell.2021.08.006

2021-09-09, Review

Abstract & Authors:展开

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The human microbiome constitutes a complex multikingdom community that symbiotically interacts with the host across multiple body sites. Host-microbiome interactions impact multiple physiological processes and a variety of multifactorial disease conditions. In the past decade, microbiome communities have been suggested to influence the development, progression, metastasis formation, and treatment response of multiple cancer types. While causal evidence of microbial impacts on cancer biology is only beginning to be unraveled, enhanced molecular understanding of such cancer-modulating interactions and impacts on cancer treatment are considered of major scientific importance and clinical relevance. In this review, we describe the molecular pathogenic mechanisms shared throughout microbial niches that contribute to the initiation and progression of cancer. We highlight advances, limitations, challenges, and prospects in understanding how the microbiome may causally impact cancer and its treatment responsiveness, and how microorganisms or their secreted bioactive metabolites may be potentially harnessed and targeted as precision cancer therapeutics.

First Authors:
Nyssa Cullin,Camila Azevedo Antunes

Correspondence Authors:
Christoph K Stein-Thoeringer,Eran Elinav

All Authors:
Nyssa Cullin,Camila Azevedo Antunes,Ravid Straussman,Christoph K Stein-Thoeringer,Eran Elinav

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