胖胖胖与糖尿病风险
创作:兵兵 审核:兵兵 01月04日
  • 研究纳入11192名18-23岁澳大利亚女性,每3年一次,共随访19年;
  • 平均随访16年间,共162名(1.5%)的参与者被诊断为2型糖尿病(T2D);
  • 发现6种完全不同的BMI变化轨迹模式,在基线BMI和BMI上升趋势上存在差异;
  • 基线BMI和肥胖年限与T2D风险呈正相关,肥胖发生时的年龄则与T2D呈负相关;
  • 校正样本数、膳食、纤维素摄入以及血糖指数等,上述结果不变;
  • 避免肥胖、延迟肥胖发生年龄以及减少肥胖持续年限,或可很大程度降低T2D风险。
主编推荐语
兵兵
本研究聚焦18-23岁的青年女性,发现BMI基数、肥胖发生时的年龄以及肥胖的持续暴露年限,均与2型糖尿病风险相关。文章呼吁青年人注意自己的体重,避免肥胖发生,尽可能推迟肥胖的到来。
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Diabetologia [IF:7.113]

Age of obesity onset, cumulative obesity exposure over early adulthood and risk of type 2 diabetes

青年期的肥胖起始年龄、肥胖积累暴露与2型糖尿病的风险

10.1007/s00125-019-05058-7

2019-12-20, Article

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Aims/hypothesis: Obesity is a risk factor for type 2 diabetes, yet little is known about how timing and cumulative exposure of obesity are related to disease risk. The aim of this study was to examine the associations between BMI trajectories, age of onset of obesity and obese-years (a product of degree and duration of obesity) over early adulthood and subsequent risk of type 2 diabetes.
Methods: Women aged 18–23 years at baseline (n = 11,192) enrolled in the Australian Longitudinal Study on Women’s Health (ALSWH) in 1996 were followed up about every 3 years via surveys for up to 19 years. Self-reported weights were collected up to seven times. Incident type 2 diabetes was self-reported. A growth mixture model was used to identify distinct BMI trajectories over the early adult life course. Cox proportional hazards regression models were used to examine the associations between trajectories and risk of diabetes.
Results: One hundred and sixty-two (1.5%) women were newly diagnosed with type 2 diabetes during a mean of 16 years of follow-up. Six distinct BMI trajectories were identified, varying by different initial BMI and different slopes of increase. Initial BMI was positively associated with risk of diabetes. We also observed that age at onset of obesity was negatively associated with risk of diabetes (HR 0.87 [95% CI 0.79, 0.96] per 1 year increment), and number of obese-years was positively associated with diabetes (p for trend <0.0001).
Conclusions/interpretation: Our data revealed the importance of timing of obesity, and cumulative exposure to obesity in the development of type 2 diabetes in young women, suggesting that preventing or delaying the onset of obesity and reducing cumulative exposure to obesity may substantially lower the risk of developing diabetes.

First Authors:
Juhua Luo

Correspondence Authors:
Juhua Luo

All Authors:
Juhua Luo,Allison Hodge,Michael Hendryx,Julie E Byles

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