生酮饮食减肥时,不同类型蛋白质对健康有不同影响
创作:szx 审核:szx 2020年06月21日
  • 48名肥胖患者随机均分为3组,在进行极低卡路里生酮饮食(VLCKD)干预中,分别添加乳清、蔬菜或动物蛋白,持续45天;
  • 所有患者在VLCKD干预后,体重、BMI、血压、腰围、胰岛素抵抗、胰岛素、总胆固醇、LDL胆固醇均降低,厚壁菌门相对丰度降低,而拟杆菌门相对丰度增加;
  • 添加乳清蛋白的患者的肌肉强度有更明显的提升,添加动物蛋白的患者的肾功能标志物轻微恶化,菌群变化也较不明显。
主编推荐语
szx
Journal of Clinical Endocrinology and Metabolism上发表的一项RCT结果,48名肥胖患者进行45天的极低卡路里生酮饮食干预后,体重及各代谢指标均得到显著改善。对于不同的蛋白来源,以蔬菜蛋白为蛋白来源的饮食干预可使患者有更健康的菌群组成,而以动物蛋白为蛋白来源的饮食干预可能对患者的肾功能有不利影响,以乳清蛋白为蛋白来源的饮食干预则可能增强患者的肌肉强度。
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Very-Low-Calorie Ketogenic Diets with Whey, Vegetable or Animal Protein in Patients with Obesity: A Randomized Pilot Study

添加乳清、蔬菜或动物蛋白的极低卡路里生酮饮食用于肥胖患者

10.1210/clinem/dgaa336

2020-06-02, Article

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Context: We compared the efficacy, safety and effect of 45-day isocaloric very-low-calorie ketogenic diets (VLCKDs) incorporating whey, vegetable or animal protein on the microbiota in patients with obesity and insulin resistance to test the hypothesis that protein source may modulate the response to VLCKD interventions.
Subjects and Methods: Forty-eight patients with obesity [19 males and 29 females, HOMA index ≥ 2.5, age 56.2±6.1 years, body mass index (BMI) 35.9±4.1 kg/m2] were randomly assigned to three 45-day isocaloric VLCKD regimens (≤800 kcal/day) containing whey, plant or animal protein. Anthropometric indexes; blood and urine chemistry, including parameters of kidney, liver, glucose and lipid metabolism; body composition; muscle strength; and taxonomic composition of the gut microbiome were assessed. Adverse events were also recorded.
Results: Body weight, BMI, blood pressure, waist circumference, HOMA index, insulin, and total and LDL cholesterol decreased in all patients. Patients who consumed whey protein had a more pronounced improvement in muscle strength. The markers of renal function worsened slightly in the animal protein group. A decrease in the relative abundance of Firmicutes and an increase in Bacteroidetes were observed after the consumption of VLCKDs. This pattern was less pronounced in patients consuming animal protein.
Conclusions: VLCKDs led to significant weight loss and a striking improvement in metabolic parameters over a 45-day period. VLCKDs based on whey or vegetable protein have a safer profile and result in a healthier microbiota composition than those containing animal proteins. VLCKDs incorporating whey protein are more effective in maintaining muscle performance.

First Authors:
Sabrina Basciani

Correspondence Authors:
Lucio Gnessi

All Authors:
Sabrina Basciani,Elisabetta Camajani,Savina Contini,Agnese Persichetti,Renata Risi,Loris Bertoldi,Lidia Strigari,Giancarlo Prossomariti,Mikiko Watanabe,Stefania Mariani,Carla Lubrano,Alfredo Genco,Giovanni Spera,Lucio Gnessi

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