益生菌/益生元/发酵食品能改善认知功能吗?
创作:orchid 审核:szx 2020年09月09日
  • 纳入11项益生菌相关研究(n=724)、5项益生元相关研究(n=355)、6项发酵食品相关研究(n=472)进行荟萃分析;
  • 22项研究中有14项报告了对特定认知领域(包括工作记忆、注意力/警惕性、记忆准确性、记忆效率、精神运动速度、执行功能)的显著改善;
  • 但荟萃分析结果显示,益生菌、益生元及发酵食品对整体认知及各特定认知领域均无显著影响;
  • 22项研究中的16项偏倚风险较低。
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szx
Neuroscience and Biobehavioral Reviews上发表的一项荟萃分析结果,总结了22项RCT(共涉及1551名受试者)的数据后发现,益生菌、益生元或发酵食品对认知功能并无显著改善作用。
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Prebiotics, probiotics, fermented foods and cognitive outcomes: A meta-analysis of randomized controlled trials

益生元、益生菌、发酵食品和认知结果:随机对照试验的荟萃分析

10.1016/j.neubiorev.2020.07.036

2020-08-27, Review

Abstract & Authors:展开

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This systematic review and meta-analysis aimed to evaluate randomized controlled trials that investigated the use of probiotic, prebiotic, and fermented food interventions for cognitive performance. In total, 22 studies (n = 1551) were included that investigated probiotics (11 studies, n = 724), prebiotics (5 studies, n = 355), and fermented foods (6 studies, n = 472). Despite several individual studies (14 of 22) reporting significant improvements in specific cognitive domains, results of the pooled meta-analysis found no significant effect for any intervention for global cognition (Probiotics: g = 0.115, 95 %CI -0.041, 0.270, p = 0.148; Prebiotics: g = 0.077, 95 %CI -0.091, 0.246, p = 0.369; Fermented food: g = 0.164 95 %CI -0.017, 0.345, p = 0.076) or any individual cognitive domain. Most studies (16 of 22) had low risk of bias. These results do not support the use of probiotic, prebiotic, and fermented food interventions for cognitive outcomes. This may be due to the limited number of small and short-term studies as well clinical heterogeneity relating to the population, cognitive tests, and intervention. Therefore, further trials that investigate these interventions in clinical populations using adequately powered samples are warranted.

First Authors:
Wolfgang Marx

Correspondence Authors:
Wolfgang Marx

All Authors:
Wolfgang Marx,Andrew Scholey,Joseph Firth,Nathan M D'Cunha,Melissa Lane,Meghan Hockey,Melanie M Ashton,John F Cryan,Adrienne O'Neil,Nenad Naumovski,Michael Berk,Olivia M Dean,Felice Jacka

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