Immunity:研究肠粘膜免疫的重量级新方法
创作:FU 审核:爱的抉择 2016年05月19日
  • 炎性肠道疾病的特征是异常的免疫反应,虽然已经鉴定出几种免疫亚群能驱动胃肠道病理学发展,但仍缺乏系统分析;
  • 采用质谱流式细胞技术对健康和疾病状态的人粘膜免疫系统进行分析,构建人粘膜免疫系统的全系统图谱;
  • 共区分142个免疫亚群,从外周血单核细胞和肠道样品中鉴定出一些免疫细胞亚群可区分病人和对照,并鉴定出粘膜淋巴恶性肿瘤及其前体;
  • 鉴定组织及疾病相关性的免疫亚群,有助于诊断、免疫监控以及肠道疾病的治疗。
主编推荐语
蓝灿辉 | 热心肠先生
绝对重量级新方法,小秘书不太懂,不过肠sir说是重量级,我觉得应该是重量级吧。肠sir还说,做益生元、益生菌的人,可以用这个新方法研究下自己的产品到底对肠道粘膜免疫细胞有什么影响哦。
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Immunity [IF:22.553]

Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets

通过质谱流式细胞技术从人体粘膜免疫系统中鉴定出组织及疾病相关性免疫亚群

10.1016/j.immuni.2016.04.014

2016-05-17, Article

Abstract & Authors:展开

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BACKGROUND: Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a single-cell basis is lacking.
METHODS: We used high-dimensional mass cytometry to generate a system-wide view of the human mucosal immune system in health and disease.
RESULTS: We distinguished 142 immune subsets and through computational applications found distinct immune subsets in peripheral blood mononuclear cells and intestinal biopsies that distinguished patients from controls. In addition, mucosal lymphoid malignancies were readily detected as well as precursors from which these likely derived.
CONCLUSION: These findings indicate that an integrated high-dimensional analysis of the entire immune system can identify immune subsets associated with the pathogenesis of complex intestinal disorders. This might have implications for diagnostic procedures, immune-monitoring, and treatment of intestinal diseases and mucosal malignancies.

First Authors:
Vincent van Unen

Correspondence Authors:
Frits Koning

All Authors:
Vincent van Unen,Na Li,Ilse Molendijk,Mine Temurhan,Thomas Höllt,Andrea E van der Meulen-de Jong,Hein W Verspaget,M Luisa Mearin,Chris J Mulder,Jeroen van Bergen,Boudewijn P F Lelieveldt,Frits Koning

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