CTI:TGF-β如何调节肠道菌群及免疫细胞?(综述)
创作:康康先生 审核:szx 2017年05月01日
  • 肠道菌群与宿主的免疫细胞之间通过化学分子和信号的产生与释放直接或间接地相互制约;
  • 本综述明确了β-转化生长因子(TGF-β)对这种复杂的相互作用的功能影响;
  • SPF小鼠比无菌小鼠的TGF-β水平显著升高,肠道上皮细胞(IEC)可能是肠道中的TGF-β的主要来源;
  • TGF-β可能通过局部对调节型T细胞(Treg细胞)、辅助型T细胞(Th17细胞)、先天型T细胞(ILCs细胞)与B细胞之间的活性调节,从而影响肠道菌群-宿主的互作。
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Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions

β-转化生长因子(TGF-β):主要调节肠道菌群与免疫细胞的相互作用

10.1038/cti.2017.9

2017-04-07, Review

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The relationship between host organisms and their microbiota has co-evolved towards an inter-dependent network of mutualistic interactions. This interplay is particularly well studied in the gastrointestinal tract, where microbiota and host immune cells can modulate each other directly, as well as indirectly, through the production and release of chemical molecules and signals. In this review, we define the functional impact of transforming growth factor-beta (TGF-β) on this complex interplay, especially through its modulation of the activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate lymphoid cells (ILCs) and B cells.

First Authors:
David Bauché

Correspondence Authors:
Julien C Marie

All Authors:
David Bauché,Julien C Marie

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