Science子刊:石墨烯量子点或可治疗结肠炎
创作:勒布朗 审核:爱的抉择 05月27日
  • 构建葡聚糖硫酸钠诱导小鼠慢性和急性结肠炎模型,腹腔注射石墨烯量子点(GQDs)可显著改善肠炎症状;
  • 机制上,GQDs通过抑制Th1/Th17的极化、ROS产生等有效预防组织变性,改善肠道炎症;
  • 同时GQDs将巨噬细胞的极化从经典激活途径M1切换到M2,导致肠组织Tregs浸润增加,抑制激活的促炎免疫细胞和炎症的发生,促进组织愈合;
  • GQDs对小鼠的整体健康没有毒性作用,且能够自然排出到体外;
  • GQDs或可作为治疗IBD等自身免疫疾病的替代药物。
主编推荐语
爱的抉择
石墨烯及其衍生物在多种仿生模型中被证实是潜在的纳米药物,而石墨烯量子点(GQDs)具有体内毒性低、易清除等特点,适合用于治疗肠道疾病。Science Advances最新发表文章显示,GQDs可显著改善小鼠结肠炎症状,并揭示出GQDs通过调控免疫细胞有效缓解过度炎症的作用机制,提示GQDs或可作为治疗IBD等自身免疫疾病的替代性药物。
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Science advances [IF:13.116]

Graphene quantum dots as anti-inflammatory therapy for colitis

石墨烯量子点应用于结肠炎的抗炎治疗

10.1126/sciadv.aaz2630

04-29, Article

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Abstract:收起
While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles in immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of their low toxicity in vivo and ease of clearance. Here, GQDs are intraperitoneally injected to dextran sulfate sodium (DSS)–induced chronic and acute colitis model, and its efficacy has been confirmed. In particular, GQDs effectively prevent tissue degeneration and ameliorate intestinal inflammation by inhibiting TH1/TH17 polarization. Moreover, GQDs switch the polarization of macrophages from classically activated M1 to M2 and enhance intestinal infiltration of regulatory T cells (Tregs). Therefore, GQDs effectively attenuate excessive inflammation by regulating immune cells, indicating that they can be used as promising alternative therapeutic agents for the treatment of autoimmune disorders, including IBDs.

First Authors:
Byung-Chul Lee,Jin Young Lee

Correspondence Authors:
Byung Hee Hong,Kyung-Sun Kang

All Authors:
Byung-Chul Lee,Jin Young Lee,Juhee Kim,Je Min Yoo,Insung Kang,Jae-Jun Kim,Nari Shin,Dong Jin Kim,Soon Won Choi,Donghoon Kim,Byung Hee Hong,Kyung-Sun Kang

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