与地中海饮食依从性相关的血浆代谢产物特征可用于预测心血管疾病风险
创作:szx 审核:szx 2020年06月06日
  • 纳入1859名西班牙受试者作为研究队列,6868名美国受试者作为验证队列;
  • 在分析的302种血浆代谢产物中,鉴定出97种与西班牙受试者的地中海饮食依从性显著相关;
  • 鉴定出一个包含67种血浆代谢产物的代谢特征,在两个队列中均与地中海饮食依从性显著相关;
  • 该代谢特征与心血管疾病的发病率呈显著负相关,并与脂肪酸及氨基酸代谢相关的遗传位点有显著关联。
  • 孟德尔随机化分析显示,遗传推测的代谢特征与冠心病及中风的风险显著相关。
主编推荐语
szx
《European Heart Journal》上发表的一项队列研究,在包含近2000名西班牙受试者的研究队列及包含近7000名美国受试者的验证队列中发现,一个包含67种血浆代谢产物(主要为脂质及氨基酸)的代谢特征与地中海饮食依从性显著相关,该代谢特征与心血管疾病风险呈显著负相关。
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The Mediterranean diet, plasma metabolome, and cardiovascular disease risk

地中海饮食、血浆代谢组及心血管疾病风险

10.1093/eurheartj/ehaa209

2020-05-14, Article

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Aims: To investigate whether metabolic signature composed of multiple plasma metabolites can be used to characterize adherence and metabolic response to the Mediterranean diet and whether such a metabolic signature is associated with cardiovascular disease (CVD) risk.
Methods and results: Our primary study cohort included 1859 participants from the Spanish PREDIMED trial, and validation cohorts included 6868 participants from the US Nurses’ Health Studies I and II, and Health Professionals Follow-up Study (NHS/HPFS). Adherence to the Mediterranean diet was assessed using a validated Mediterranean Diet Adherence Screener (MEDAS), and plasma metabolome was profiled by liquid chromatography-tandem mass spectrometry. We observed substantial metabolomic variation with respect to Mediterranean diet adherence, with nearly one-third of the assayed metabolites significantly associated with MEDAS (false discovery rate < 0.05). Using elastic net regularized regressions, we identified a metabolic signature, comprised of 67 metabolites, robustly correlated with Mediterranean diet adherence in both PREDIMED and NHS/HPFS (r = 0.28–0.37 between the signature and MEDAS; P = 3 × 10−35 to 4 × 10−118). In multivariable Cox regressions, the metabolic signature showed a significant inverse association with CVD incidence after adjusting for known risk factors (PREDIMED: hazard ratio [HR] per standard deviation increment in the signature = 0.71, P < 0.001; NHS/HPFS: HR = 0.85, P = 0.001), and the association persisted after further adjustment for MEDAS scores (PREDIMED: HR = 0.73, P = 0.004; NHS/HPFS: HR = 0.85, P = 0.004). Further genome-wide association analysis revealed that the metabolic signature was significantly associated with genetic loci involved in fatty acids and amino acids metabolism. Mendelian randomization analyses showed that the genetically inferred metabolic signature was significantly associated with risk of coronary heart disease (CHD) and stroke (odds ratios per SD increment in the genetically inferred metabolic signature = 0.92 for CHD and 0.91 for stroke; P < 0.001).
Conclusions: We identified a metabolic signature that robustly reflects adherence and metabolic response to a Mediterranean diet, and predicts future CVD risk independent of traditional risk factors, in Spanish and US cohorts.

First Authors:
Jun Li

Correspondence Authors:
Frank B Hu,Liming Liang

All Authors:
Jun Li,Marta Guasch-Ferré,Wonil Chung,Miguel Ruiz-Canela,Estefanía Toledo,Dolores Corella,Shilpa N Bhupathiraju,Deirdre K Tobias,Fred K Tabung,Jie Hu,Tong Zhao,Constance Turman,Yen-Chen Anne Feng,Clary B Clish,Lorelei Mucci,A Heather Eliassen,Karen H Costenbader,Elizabeth W Karlson,Brian M Wolpin,Alberto Ascherio,Eric B Rimm,JoAnn E Manson,Lu Qi,Miguel Angel Martínez-González,Jordi Salas-Salvadó,Frank B Hu,Liming Liang

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