膳食或影响受孕率
创作:兵兵 审核:兵兵 01月08日
  • 研究纳入2709和4268对分别来自SF队列和PRESTO 队列的夫妇;
  • 与平均每日血糖负荷100及以下相比,两个队列中该值在141及以上的受孕率(FRs)分别为0.89和0.87;
  • 与平均每天摄入16g及以下膳食纤维相比,两个队列中该值为25g及以上的FRs分别为0.99和1.06;
  • 与碳水化合物/膳食纤维比为8及以下相比,两个队列中该比例在13及以上的FRs分别为0.86和0.87;
  • 与每天摄入27g及以下添加糖相比,两个队列中该值在72g及以上的FRs分别为0.87和0.86。
主编推荐语
兵兵
文章纳入两个孕前队列,研究了血糖负荷与受孕率的相关性。其中,与血糖负荷相关的膳食纤维以及添加糖的摄入也参与比较研究。研究结果表明,高的血糖负荷、碳水化合物/纤维素比以及添加糖的摄入与受孕率降低有关。
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Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts

两项孕前队列研究:血糖负荷、膳食纤维、添加糖与受孕率

10.1093/ajcn/nqz312

01-04, Article

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Background: Glycemic load (GL) reflects the quantity and quality of carbohydrates in the diet; dietary fiber and added sugar are components of GL. Few epidemiologic studies have assessed the association between these dietary factors and fecundability.
Objective: We prospectively evaluated the associations of GL, total carbohydrates, dietary fiber, and added sugar with fecundability.
Methods: Snart Foraeldre (SF) and Pregnancy Study Online (PRESTO) are parallel web-based prospective preconception cohorts of couples attempting to conceive in Denmark and North America. At baseline, female participants completed a web-based questionnaire on demographic and lifestyle factors and a validated FFQ. We calculated GL, total carbohydrate intake, total dietary fiber, carbohydrate-to-fiber ratio, and added sugar based on reported frequencies for individual foods, standard recipes for mixed foods, and average serving sizes. The analysis included 2709 SF participants and 4268 PRESTO participants. We used proportional probabilities regression models to estimate fecundability ratios (FR) and 95% CIs.
Results: Compared with an average daily GL of ≤100, FRs for an average daily GL of ≥141 were 0.89 (95% CI: 0.73, 1.08) in SF and 0.87 (95% CI: 0.77, 0.98) in PRESTO participants. Compared with consuming ≤16 g/d of dietary fiber, FRs for consuming ≥25 g/d were 0.99 (95% CI: 0.81, 1.22) in SF and 1.06 (95% CI: 0.94, 1.20) in PRESTO. Compared with a carbohydrate-to-fiber ratio of ≤8, FRs for a ratio of ≥13 were 0.86 (95% CI: 0.73, 1.01) in SF and 0.87 (95% CI: 0.78, 0.98) in PRESTO. Compared with ≤27 g/d of added sugar, FRs for ≥72 g/d were 0.87 (95% CI: 0.68, 1.10) in SF and 0.86 (95% CI: 0.75, 0.99) in PRESTO participants.
Conclusions: Among women attempting to conceive in Denmark and North America, diets high in GL, carbohydrate-to-fiber ratio, and added sugar were associated with modestly reduced fecundability.

First Authors:
Sydney K Willis

Correspondence Authors:
Sydney K Willis

All Authors:
Sydney K Willis,Lauren A Wise,Amelia K Wesselink,Kenneth J Rothman,Ellen M Mikkelsen,Katherine L Tucker,Ellen Trolle,Elizabeth E Hatch

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